Pharmaceutical Production of Anti-tumor and Immune-potentiating Enterococcus faecalis-2001 beta-glucans: Enhanced Activity of Macrophage and Lymphocytes in Tumor-implanted Mice
- Authors
- Gu, YH[Gu, Yeun-Hwa]; Choi, H[Choi, Hyunju]; Yamashita, T[Yamashita, Takenori]; Kang, KM[Kang, Ki-Mun]; Iwasa, M[Iwasa, Masahiro]; Lee, MJ[Lee, Moon-Jo]; Lee, KH[Lee, Kyoung Hae]; Kim, CH[Kim, Cheorl-Ho]
- Issue Date
- 2017
- Publisher
- BENTHAM SCIENCE PUBL LTD
- Citation
- CURRENT PHARMACEUTICAL BIOTECHNOLOGY, v.18, no.8, pp.653 - 661
- Indexed
- SCIE
SCOPUS
- Journal Title
- CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Volume
- 18
- Number
- 8
- Start Page
- 653
- End Page
- 661
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/33274
- DOI
- 10.2174/1389201018666171002130428
- ISSN
- 1389-2010
- Abstract
- Background: Enterococcus faecalis 2001 is a probiotic lactic acid bacterium and has been used as a biological response modifier (BRM). From physiological limitation of bacterial preservation in storage and safety, the live E. faecalis 2001 has been heat-treated and the BRM components containing high level of beta-glucan, named EF-2001, were prepared. Method: The heat-treated EF-2001 has been examined for the antioxidative potential for radical scavenging and anti-tumor activities as well as immune-enhancing response in mice. Lymphocyte versus polymorphonuclear leukocyte ratio was increased in mice upon treatment with EF-2001. The number of lymphocytes was increased in the EF-2001-treated group. In the mice bearing two different Ehrlich solid and Sarcoma-180 carcinomas, the treatment with EF-2001 resulted in anti-tumor action. Tumor-suppressive capacity upon treatment with EF-2001 was significantly increased compared to normal controls. Results: During the time interval administration of 5 weeks between the priming and secondary administration of EF-2001, the expression and production levels of TNF-alpha were also observed in the EF2001-administered mice. Additionally, anti-tumor activity examined with the intravenous administration of EF 2001 with a 34 times interval was also observed, as the growth of Sarcoma180 cells was clearly inhibited by the EF-2001. Conclusion: From the results, it was suggested that the immune response is enhanced due to antioxidative activity caused by the EF-2001 and anti-tumor activity by NK cells and TNF-alpha.
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Collections - Science > Department of Biological Science > 1. Journal Articles
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