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How many mcr-1-harbouring bacteria were spreading geographically?
- Authors
- Park, K.S.[Park, K.S.]; Lee, J.H.[ Lee, J.H.]; Park, M.[ Park, M.]; Ko, K.S.[Ko, K.S.]; Lee, S.H.[ Lee, S.H.]
- Issue Date
- 2017
- Publisher
- Scientific Publishers of India
- Keywords
- Dissemination; Epidemiology; Mcr-1; Plasmid-mediated colistin resistance; PmrC
- Citation
- Biomedical Research (India), v.28, no.4, pp.1659 - 1663
- Indexed
- SCIE
SCOPUS
- Journal Title
- Biomedical Research (India)
- Volume
- 28
- Number
- 4
- Start Page
- 1659
- End Page
- 1663
- ISSN
- 0970-938X
- Abstract
- Colistin is widely used as an antibiotic of last resort for treating infections caused by multidrug-resistant gram-negative bacteria such as carbapenemase-producing Enterobacteriaceae. Recently, the emergence of plasmid-mediated (horizontally-transferable) colistin resistance (mcr-1) has become a great challenge to global public health. The mcr-1 gene was detected in ESBL (Extended Spectrum β-Lactamase)-producing and/or carbapenemase-producing Enterobacteriaceae. Therefore, there is a huge risk of the emergence of pan-drug-resistant gram-negative bacteria. In this paper we discuss the epidemiological analyses of mcr-1 positive Enterobacteriaceae and structural analyses of PmrC that was recently identified as a protein associated with colistin resistance. © 2017, Scientific Publishers of India. All rights reserved.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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