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Expression Pattern of Smad4/GATA3 as a Predictor of Survival in Invasive Ductal Carcinoma of the Breast
- Authors
- Min, KW[Min, Kyueng-Whan]; Kim, DH[Kim, Dong-Hoon]; Do, SI[Do, Sung-Im]; Chae, SW[Chae, Seoung Wan]; Kim, K[Kim, Kyungeun]; Sohn, JH[Sohn, Jin Hee]; Lee, HJ[Lee, Hyun Joo]; Do, IG[Do, In-Gu]; Pyo, JS[Pyo, Jung-Soo]; Kim, Y[Kim, Yuil]; Kim, DH[Kim, Dong Hyun]; Yang, JH[Yang, Jung-Ho]; Lee, SJ[Lee, Sang-Jo]; Oh, YH[Oh, Young Ha]; Oh, S[Oh, Sukjoong]; Choi, SH[Choi, Seon Hyeong]; Park, YL[Park, Yong Lai]; Park, CH[Park, Chan Heun]; Kim, EK[Kim, Eun-Kyung]; Kwon, MJ[Kwon, Mi Jung]; Seo, J[Seo, Jinwon]
- Issue Date
- 2017
- Publisher
- KARGER
- Keywords
- Smad4 protein; GATA3 protein; Prognosis; Breast cancer
- Citation
- PATHOBIOLOGY, v.84, no.3, pp.130 - 138
- Indexed
- SCIE
SCOPUS
- Journal Title
- PATHOBIOLOGY
- Volume
- 84
- Number
- 3
- Start Page
- 130
- End Page
- 138
- ISSN
- 1015-2008
- Abstract
- Background: Smad4 and GATA3 proteins are known prognostic markers in various cancers. Smad4 is a mediator linked to both tumour suppression and progression. GATA3 is a regulator of development and morphogenesis of the mammary gland. We assessed and compared the predictive performance of Smad4 and GATA3 for clinical outcomes in patients with breast cancer. Methods: The combined expression pattern based on Smad4+/- and GATA3+/- was evaluated by immunostaining using breast cancer tissue microarray, and the relationships between protein expression and clinicopathological variables were analysed. Results: Smad4 expression was only associated with an ill-defined tumour border, whereas GATA3 was associated with several good prognostic factors. On analysis of combined markers, there was a significant difference in the expression of fascin (an important factor for cancer invasiveness) between the Smad4+/GATA3- and Smad4-/GATA3+ groups. Smad4+/GATA3- was correlated with worse clinicopathological parameters, relapse-free survival (RFS), and overall survival (OS), compared to Smad4-/GATA3+. Conclusion: Combined markers of Smad4/GATA3 showed a superior performance compared to single markers for predicting RFS and OS in patients with breast cancer. (C) 2017 S. Karger AG, Basel
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