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pH-Responsive globular poly(ethylene glycol) for photodynamic tumor therapy
- Authors
- Ku, EB[Ku, Eun Bi]; Lee, DJ[Lee, Dong Jin]; Na, K[Na, Kun]; Choi, SW[Choi, Sung-Wook]; Youn, YS[Youn, Yu Seok]; Bae, SK[Bae, Soo Kyung]; Oh, KT[Oh, Kyung Taek]; Lee, ES[Lee, Eun Seong]
- Issue Date
- 1-Dec-2016
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Globular poly(ethylene glycol); 2,3-dimethylmaleic acid; Chlorin e6; Photodynamic tumor therapy
- Citation
- COLLOIDS AND SURFACES B-BIOINTERFACES, v.148, pp.173 - 180
- Indexed
- SCIE
SCOPUS
- Journal Title
- COLLOIDS AND SURFACES B-BIOINTERFACES
- Volume
- 148
- Start Page
- 173
- End Page
- 180
- ISSN
- 0927-7765
- Abstract
- In this study, we report the development of extremely small-sized globular poly(ethylene glycol) (gPEG) that can specifically recognize tumor acidic pH. gPEG coupled with chlorin e6 (Ce6, a photosensitizing drug) and 2,3-dimethylmaleic acid (DMA, as a pH-responsive moiety) (gPEG-Ce6-DMA, particle size: 3-4 nm in diameter) was easily dispersed in phosphate buffered saline (PBS) without any of the nanoparticle fabrication steps. We observed that gPEG-Ce6-DMA displayed pH-dependent zeta-potential changes due to coupling (at pH 7.4) or decoupling (at pH 6.8-6.0) of DMA. As a result, the uptake of gPEG-Ce6-DMA was significantly increased in tumors at acidic pH, likely due to the decoupling of DMA (backing cationic primary amines). As a result, the preferential cellular uptake of gPEG-Ce6-DMA at acidic pH allowed for a significant enhancement of in vitro/in vivo photodynamic tumor cell ablation under light illumination. (C) 2016 Elsevier B.V. All rights reserved.
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