Gold-Nanoclustered Hyaluronan Nano-Assemblies for Photothermally Maneuvered Photodynamic Tumor Ablation
- Authors
- Han, H.S.[Han, H.S.]; Choi, K.Y.[Choi, K.Y.]; Lee, H.[Lee, H.]; Lee, M.[Lee, M.]; An, J.Y.[An, J.Y.]; Shin, S.[Shin, S.]; Kwon, S.[Kwon, S.]; Lee, D.S.[Lee, D.S.]; Park, J.H.[Park, J.H.]
- Issue Date
- Dec-2016
- Publisher
- AMER CHEMICAL SOC
- Keywords
- gold; hyaluronan; hybrid nanomaterials; photodynamic therapy; photothermal therapy
- Citation
- ACS NANO, v.10, no.12, pp.10858 - 10868
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS NANO
- Volume
- 10
- Number
- 12
- Start Page
- 10858
- End Page
- 10868
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/34137
- DOI
- 10.1021/acsnano.6b05113
- ISSN
- 1936-0851
- Abstract
- Optically active nanomaterials have shown great promise as a nanomedicine platform for photothermal or photodynamic cancer therapies. Herein, we report a gold-nanoclustered hyaluronan nano assembly (GNc-HyNA) for photothermally boosted photodynamic tumor ablation. Unlike other supramolecular gold constructs based on gold nanoparticle building blocks, this system utilizes the nanoassembly of amphiphilic hyaluronan conjugates as a drug carrier for a hydrophobic photodynamic therapy agent verteporfin, a polymeric reducing agent, and an organic nanoscaffold upon which gold can grow. Gold nanoclusters were selectively installed on the outer shell of the hyaluronan nanoassembly, forming a gold shell. Given the dual protection effect by the hyaluronan self-assembly as well as by the inorganic gold shell, verteporfin-encapsulated GNc-HyNA (Vp-GNc-HyNA) exhibited outstanding stability in the bloodstream. Interestingly, the fluorescence and photodynamic properties of Vp-GNc-HyNA were considerably quenched due to the gold nanoclusters covering the surface of the nanoassemblies; however, photothermal activation by 808 nm laser irradiation induced a significant increase in temperature, which empowered the PDT effect of Vp-GNc-HyNA. Furthermore, fluorescence and photodynamic effects were recovered far more rapidly in cancer cells due to certain intracellular enzymes, particularly hyaluronidases and glutathione. Vp-GNc-HyNA exerted a great potential to treat tumors both in vitro and in vivo. Tumors were completely ablated with a 100% survival rate and complete skin regeneration over the 50 days following Vp-GNc-HyNA treatment in an orthotopic breast tumor model. Our results suggest that photothermally boosted photodynamic therapy using Vp-GNc-HyNA can offer a potent therapeutic means to eradicate tumors.
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Collections - Engineering > School of Chemical Engineering > 1. Journal Articles
- Engineering > Chemical Engineering > 1. Journal Articles
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