Clinical features and treatment outcome of Epstein-Barr virus-positive nodal T-cell lymphoma
- Authors
- Jung, KS[Jung, Ki Sun]; Cho, SH[Cho, Su-Hee]; Kim, SJ[Kim, Seok Jin]; Ko, YH[Ko, Young Hyeh]; Kim, WS[Kim, Won Seog]
- Issue Date
- Nov-2016
- Publisher
- SPRINGER JAPAN KK
- Keywords
- Epstein-Barr virus; Mature NK-/T-cell lymphoma; Survival; Cyclophosphamide-containing regimen
- Citation
- INTERNATIONAL JOURNAL OF HEMATOLOGY, v.104, no.5, pp.591 - 595
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF HEMATOLOGY
- Volume
- 104
- Number
- 5
- Start Page
- 591
- End Page
- 595
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/34640
- DOI
- 10.1007/s12185-016-2068-1
- ISSN
- 0925-5710
- Abstract
- The classification of mature NK-/T-cell lymphoma mainly originating from the T-cell lineage with predominantly nodal involvement and Epstein-Barr virus (EBV) positivity in a majority of tumor cells is unresolved. We analyzed the clinical features and treatment outcomes of such patients. Five patients with EBV-positive nodal T-cell lymphoma were surveyed during follow-up period. The median age was 53 years (range 33-88 years), and all patients showed nodal involvement. The patients mostly presented advanced clinical features, such as stage III or IV disease, elevated lactate dehydrogenase, and hemophagocytosis. Four patients received cyclophosphamide-containing chemotherapy at the time of diagnosis. However, three patients (75 %) showed disease progression during the early cycles of initial treatment. The median overall survival was 1.5 months (95 % CI 0.0-3.4 months). Patients with EBV-positive nodal T-cell lymphoma mainly show lymph node involvement, but also show aggressive clinical features and poor treatment outcomes, such as aggressive NK-cell leukemia. Therefore, we should consider EBV-positive nodal T-cell lymphoma to be a unique disease entity distinct from peripheral T-cell lymphoma not otherwise specified.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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