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An Implantable Wireless Interstitial Pressure Sensor With Integrated Guyton Chamber: in vivo Study in Solid Tumors
- Authors
- Song, SH[Song, Seung Hyun]; Kim, A[Kim, Albert]; Brown, M[Brown, Marcus]; Jung, C[Jung, Chaeyong]; Ko, S[Ko, S.]; Ziaie, B[Ziaie, Babak]
- Issue Date
- Nov-2016
- Publisher
- IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
- Keywords
- Angiogenesis inhibitors; cancer; chemotherapy; interstitial fluid pressure; implantable pressure sensor; wireless pressure sensor; vascular endothelial growth factor (VEGF)
- Citation
- IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, v.63, no.11, pp.2273 - 2277
- Indexed
- SCIE
SCOPUS
- Journal Title
- IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
- Volume
- 63
- Number
- 11
- Start Page
- 2273
- End Page
- 2277
- ISSN
- 0018-9294
- Abstract
- A wireless implantable interstitial fluid pressure (IFP) sensor with an integrated Guyton chamber is presented. This implantable device enables noninvasive and continuous measurements of IFP. The Guyton chamber allows for an accurate measurement of IFP without the interference from various cellular/tissue components. The sensor consists of a coil, an air chamber, a silicone membrane embedded with a nickel plate, and a Guyton chamber. The fabricated device is 3 mm in diameter and 1 mm in thickness. The sensor shows a linear response to the pressure with a sensitivity of 60 kHz/mmHg and a resolution of 1 mmHg. Experiments in human prostate cancer tumors grown in mice confirm the sensor's capability to operate in vivo and provide continuous wireless measurement of IFP, a surrogate parameter indicating the "window of opportunity" for delivering chemo-and radio-therapeutic agents.
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