Family History and Risk of Recurrent Stroke
- Authors
- Chung J.-W.[Chung J.-W.]; Kim B.J.[Kim B.J.]; Han M.-K.[Han M.-K.]; Kang K.[Kang K.]; Park J.-M.[Park J.-M.]; Park S.-S.[Park S.-S.]; Park T.H.[Park T.H.]; Cho Y.-J.[Cho Y.-J.]; Hong K.-S.[Hong K.-S.]; Lee K.B.[Lee K.B.]; Kim J.G.[Kim J.G.]; Ko Y.[Ko Y.]; Lee S.[Lee S.]; Nah H.-W.[Nah H.-W.]; Kim D.-H.[Kim D.-H.]; Cha J.-K.[Cha J.-K.]; Oh M.-S.[Oh M.-S.]; Yu K.-H.[Yu K.-H.]; Lee B.-C.[Lee B.-C.]; Jang M.S.[Jang M.S.]; Lee J.S.[Lee J.S.]; Lee J.[Lee J.]; Bae H.-J.[Bae H.-J.]
- Issue Date
- Aug-2016
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- ischemia; prognosis; proportional hazard models; risk assessment; stroke
- Citation
- STROKE, v.47, no.8, pp.1990 - 1996
- Indexed
- SCIE
SCOPUS
- Journal Title
- STROKE
- Volume
- 47
- Number
- 8
- Start Page
- 1990
- End Page
- 1996
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/35703
- DOI
- 10.1161/STROKEAHA.116.013148
- ISSN
- 0039-2499
- Abstract
- Background and Purpose-The association between family history of stroke and stroke recurrence remains unclear. Methods-Using a web-based multicenter stroke registry database, information on history of stroke in first-degree relatives was collected prospectively for acute ischemic stroke patients who were hospitalized within 7 days of onset. The collected information was categorized as follows: type of the affected relative(s) with stroke (paternal, maternal, sibling, or 2 or more) and age of the relative's stroke onset (<50, 50-59, 60-69, and >= 70 years). Stroke recurrence was captured prospectively using a predetermined protocol. Subgroup analyses were performed according to the patient's age at the index stroke. Results-Among 7642 patients, 937 (12.3%) had a history of stroke in their first-degree relatives and 475 (6.2%: 201 within and 274 after 3 weeks from index stroke) experienced stroke recurrence (median follow-up, 365 days). In multivariable Cox proportional hazard models, overall family history was not associated with stroke recurrence (hazard ratio, 1.08; 95% confidence interval, 0.81-1.43). However, the details of their family histories, including relative's age at stroke onset (<50 years: hazard ratio, 2.14; 95% confidence interval, 1.004-4.54) and stroke history in a sibling (hazard ratio, 1.67; 95% confidence interval, 1.09-2.58), were independently associated with stroke recurrence after adjusting for potential confounders. The associations appeared to be stronger in young adults with stroke (age, <55 years) than in older stroke patients. Conclusions-This study suggests that elevated risks of recurrent stroke are associated with having relatives with early-onset stroke and siblings with stroke histories, implying that additional precautions may be needed in such populations.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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