Anticancer effect of joboksansam, Korean wild ginseng germinated from bird fecesopen access
- Authors
- Park, JG[Park, Jae Gwang]; Kang, WS[Kang, Wie-Soo]; Park, KT[Park, Kyung Tae]; Park, DJ[Park, Dong Jun]; Aravinthan, A[Aravinthan, Adithan]; Kim, JH[Kim, Jong-Hoon]; Cho, JY[Cho, Jae Youl]
- Issue Date
- Jul-2016
- Publisher
- KOREAN SOC GINSENG
- Keywords
- anticancer activity; cytotoxicity; joboksansam; Panax ginseng; survival enzyme
- Citation
- JOURNAL OF GINSENG RESEARCH, v.40, no.3, pp.304 - 308
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- Volume
- 40
- Number
- 3
- Start Page
- 304
- End Page
- 308
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/36030
- DOI
- 10.1016/j.jgr.2016.02.002
- ISSN
- 1226-8453
- Abstract
- Background: Joboksansam, Korean bird wild ginseng, is an artificially cultivated wild ginseng germinated from bird feces. Although numerous pharmacologic activities of wild ginsengs have been reported, the beneficial effect of joboksansam in cancer has not been elucidated. In this study, we investigated the in vivo and in vitro anticancer activities of joboksansam powder. Methods: To evaluate the in vivo anticancer activity of joboksansam, we established a xenograft mouse model bearing RMA cell-derived cancer. Direct cytotoxicity induced by joboksansam powder was also investigated in vitro using (3-4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide (MTT) assay. The inhibitory activity of this powder on the activation of cell survival signaling involving Akt and Src was examined with immunoblot analysis. Results: Joboksansam powder displayed strong inhibitory activity against the increased tumor size, increased weight of total body and cancer tissues, and mortality of tumor-bearing mice. Joboksansam powder also suppressed the activation of survival regulatory enzymes Akt and Src, as assessed by phosphorylation levels in the immunoblot analysis of tumor tissues. Interestingly, the viability of RMA cells in vitro was directly decreased by joboksansam treatment. Conclusion: Overall, our results strongly suggest that joboksansam powder has the potential to protect against cancer generation by direct cytotoxic effects on cancer cells resulting from suppression of cell survival signaling. Copyright (C) 2016, The Korean Society of Ginseng, Published by Elsevier.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Biotechnology and Bioengineering > Integrative Biotechnology > 1. Journal Articles
- Biotechnology and Bioengineering > Department of Genetic Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.