Extrapyramidal Signs and Cognitive Subdomains in Alzheimer Disease
- Authors
- Park, JH[Park, Jin Hong]; Myung, W[Myung, Woojae]; Choi, J[Choi, Junbae]; Kim, S[Kim, Sangha]; Chung, JW[Chung, Jae Won]; Kang, HS[Kang, Hyo Shin]; Na, DL[Na, Duk L.]; Kim, SY[Kim, Seong Yoon]; Lee, JH[Lee, Jae-Hong]; Han, SH[Han, Seol-Heui]; Choi, SH[Choi, Seong Hye]; Kim, SY[Kim, Sang Yun]; Kim, DK[Kim, Doh Kwan]
- Issue Date
- Jul-2016
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Alzheimer disease; extrapyramidal signs; cognition; attention; visuospatial
- Citation
- AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, v.24, no.7, pp.566 - 574
- Indexed
- SCIE
SSCI
SCOPUS
- Journal Title
- AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Volume
- 24
- Number
- 7
- Start Page
- 566
- End Page
- 574
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/36095
- DOI
- 10.1016/j.jagp.2016.02.051
- ISSN
- 1064-7481
- Abstract
- Objective: Extrapyramidal signs (EPS), commonly observed in Alzheimer disease (AD), predict cognitive impairment and functional decline. This study investigated the association between EPS and five cognitive subdomains in a large number of participants with AD. Design: Cross-sectional analyses of the nationwide Clinical Research of Dementia of South Korea (CREDOS) study, 2005-2012. Setting: Multicenter clinical settings. Participants: 1,737 participants with AD drawn from the CREDOS study. Measurements: The EPS group was defined by the presence of at least one EPS based on neurologic examination. We assessed five cognitive subdomains: attention, language, visuospatial function, memory, and frontal/executive function using the Seoul Neuropsychological Screening Battery-Dementia version. The associations of EPS with each cognitive subdomain were analyzed with a multiple linear regression model after controlling for confounding factors: sex, age, years of education, severity of dementia (Clinical Dementia Rating Sum of Boxes), and white matter hyperintensities. Results: 164 AD participants (9.4%) had EPS. AD participants with EPS showed lower performance compared with those without EPS in two cognitive subdomains: attention and visuospatial function. The language, memory, and frontal/executive subdomains did not differ between the EPS-positive and the EPS-negative groups. In addition, we found a significant moderating relationship between EPS and deep white matter hyperintensities on visuospatial function score. Conclusions: EPS in AD are associated with severe cognitive impairment in attention and visuospatial function. Careful screening for EPS in patients with AD may assist in prediction of cognitive profile.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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