Gastric lesions in patients with Crohn’s disease in Korea: a multicenter studyGastric lesions in patients with Crohn’s disease in Korea: a multicenter study
- Other Titles
- Gastric lesions in patients with Crohn’s disease in Korea: a multicenter study
- Authors
- 소훈섭[소훈섭]; 예병덕[예병덕]; 박영수[박영수]; 김지훈[김지훈]; 김주성[김주성]; 문원[문원]; 이강문[이강문]; 김유선[김유선]; 금보라[금보라]; 김성은[김성은]; 김경옥[김경옥]; 김은수[김은수]; 이창균[이창균]; 홍성필[홍성필]; 임종필[임종필]; 구자설[구자설]; 최창환[최창환]; 신정은[신정은]; 이보인[이보인]; 허규찬[허규찬]; 김영호[김영호]; 김현수[김현수]; 박영숙[박영숙]; 한동수[한동수]
- Issue Date
- 2016
- Publisher
- 대한장연구학회
- Keywords
- Crohn disease; Stomach; Helicobacter pylori; Gastritis; Granuloma
- Citation
- Intestinal research, v.14, no.1, pp.60 - 68
- Indexed
- SCOPUS
KCI
- Journal Title
- Intestinal research
- Volume
- 14
- Number
- 1
- Start Page
- 60
- End Page
- 68
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/39707
- ISSN
- 1598-9100
- Abstract
- Background/Aims: Gastric pathology and Helicobacter pylori (H. pylori ) infection among Asian patients with Crohn’s disease (CD) are still unclear. We evaluated gastric histologic features and frequency of H. pylori infection in Korean patients with CD. Methods: Among 492 patients with CD receiving upper gastrointestinal (GI) endoscopic evaluation in 19 Korean hospitals, we evaluated the endoscopic findings and gastric histopathologic features of 47 patients for our study. Histopathologic classification was performed using gastric biopsy tissues, and H. pylori infection was determined using the rapid urease test and histology. Results: There were 36 men (76.6%), and the median age of patients at the time of upper GI endoscopy was 23.8 years (range, 14.2–60.5). For CD phenotype, ileocolonic disease was observed in 38 patients (80.9%), and non-stricturing, nonpenetrating disease in 31 patients (66.0%). Twenty-eight patients (59.6%) complained of upper GI symptoms. Erosive gastritis was the most common gross gastric feature (66.0%). Histopathologically, H. pylori -negative chronic active gastritis (38.3%) was the most frequent finding. H. pylori testing was positive in 11 patients (23.4%), and gastric noncaseating granulomata were detectedin 4 patients (8.5%). Gastric noncaseating granuloma showed a statistically significant association with perianal abscess/fistula (P =0.0496). Conclusions: H. pylori -negative chronic active gastritis appears to be frequent among Korean patients with CD. The frequency of H. pylori infection was comparable with previous studies. An association with perianal complications suggests a prognostic value for gastric noncaseating granuloma in patients with CD.
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