The effect of breastfeeding duration and parity on the risk of epithelial ovarian cancer: A systematic review and meta-analysisopen access
- Authors
- Sung, H.K.[Sung, H.K.]; Ma, S.H.[ Ma, S.H.]; Choi, J.-Y.[ Choi, J.-Y.]; Hwang, Y.[ Hwang, Y.]; Ahn, C.[ Ahn, C.]; Kim, B.-G.[Kim, B.-G.]; Kim, Y.-M.[ Kim, Y.-M.]; Kim, J.W.[ Kim, J.W.]; Kang, S.[ Kang, S.]; Kim, J.[ Kim, J.]; Kim, T.J.[ Kim, T.J.]; Yoo, K.-Y.[ Yoo, K.-Y.]; Kang, D.[ Kang, D.]; Park, S.[ Park, S.]
- Issue Date
- 2016
- Publisher
- Korean Society for Preventive Medicine
- Citation
- Journal of Preventive Medicine and Public Health, v.49, no.6, pp.349 - 366
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Preventive Medicine and Public Health
- Volume
- 49
- Number
- 6
- Start Page
- 349
- End Page
- 366
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/40095
- DOI
- 10.3961/jpmph.16.066
- ISSN
- 1975-8375
- Abstract
- Objectives: We conducted a systematic review and meta-analysis to summarize current evidence regarding the association of parity and duration of breastfeeding with the risk of epithelial ovarian cancer (EOC). Methods: A systematic search of relevant studies published by December 31, 2015 was performed in PubMed and EMBASE. A random-effect model was used to obtain the summary relative risks (RRs) and 95% confidence intervals (CIs). Results: Thirty-two studies had parity categories of 1, 2, and ≥3. The summary RRs for EOC were 0.72 (95% CI, 0.65 to 0.79), 0.57 (95% CI, 0.49 to 0.65), and 0.46 (95% CI, 0.41 to 0.52), respectively. Small to moderate heterogeneity was observed for one birth (p<0.01; Q=59.46; I2=47.9%). Fifteen studies had breastfeeding categories of <6 months, 6-12 months, and >13 months. The summary RRs were 0.79 (95% CI, 0.72 to 0.87), 0.72 (95% CI, 0.64 to 0.81), and 0.67 (95% CI, 0.56 to 0.79), respectively. Only small heterogeneity was observed for <6 months of breastfeeding (p=0.17; Q=18.79, I2=25.5%). Compared to nulliparous women with no history of breastfeeding, the joint effects of two births and <6 months of breastfeeding resulted in a 0.5-fold reduced risk for EOC. Conclusions: The first birth and breastfeeding for <6 months were associated with significant reductions in EOC risk. Copyright © 2016 The Korean Society for Preventive Medicine.
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