Nutritional conditions regulate transcriptional activity of SF-1 by controlling sumoylation and ubiquitinationopen access
- Authors
- Lee J.[Lee J.]; Yang D.J.[Yang D.J.]; Lee S.[Lee S.]; Hammer G.D.[Hammer G.D.]; Kim K.W.[Kim K.W.]; Elmquist J.K.[Elmquist J.K.]
- Issue Date
- 2016
- Publisher
- Nature Publishing Group
- Citation
- Scientific Reports, v.6
- Indexed
- SCIE
SCOPUS
- Journal Title
- Scientific Reports
- Volume
- 6
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/41704
- DOI
- 10.1038/srep19143
- ISSN
- 2045-2322
- Abstract
- Steroidogenic factor 1 (SF-1) is a transcription factor expressed in the ventral medial nucleus of the hypothalamus that regulates energy homeostasis. However, the molecular mechanisms of SF-1 in the control of energy balance are largely unknown. Here, we show that nutritional conditions, such as the presence or absence of serum, affect SF-1 action. Serum starvation significantly decreased hypothalamic SF-1 levels by promoting ubiquitin-dependent degradation, and sumoylation was required for this process. SF-1 transcriptional activity was also differentially regulated by nutritional status. Under normal conditions, the transcriptional activity of hypothalamic SF-1 was activated by SUMO, but this was attenuated during starvation. Taken together, these results indicate that sumoylation and ubiquitination play crucial roles in the regulation of SF-1 function and that these effects are dependent on nutritional conditions, further supporting the importance of SF-1 in the control of energy homeostasis.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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