A scaffold with a bio-mimetically designed micro/nano-fibrous structure using decellularized extracellular matrix
- Authors
- Lee, H[Lee, Hyeongjin]; Yang, S[Yang, Sira]; Kim, M[Kim, Minseong]; Kim, G[Kim, GeunHyung]
- Issue Date
- 2016
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- RSC ADVANCES, v.6, no.35, pp.29697 - 29706
- Indexed
- SCIE
SCOPUS
- Journal Title
- RSC ADVANCES
- Volume
- 6
- Number
- 35
- Start Page
- 29697
- End Page
- 29706
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/41755
- DOI
- 10.1039/c5ra27845g
- ISSN
- 2046-2069
- Abstract
- Decellularized extracellular matrix (d-ECM)-based scaffolds have been extensively applied in various tissue regeneration applications because they regulate various cell functions and effectively guide new tissue formation. However, fabrication methods using d-ECM have been limited by its low processability. In this study, a new fibrous scaffold consisting of poly(epsilon-caprolactone) (PCL) and d-ECM was fabricated using an electrohydrodynamic jet process to obtain a pore-controlled multi-layered structure. In the scaffold, the d-ECM was used as a supplementary bioactive component to induce highly active cell responses. The suggested PCL/ECM fibrous structure showed significantly higher tensility (tensile modulus: 2-fold) than a pure PCL fibrous structure with a similar pore structure. The in vitro cellular responses of the fibrous structure were increased using human fibroblasts, and the ECM-based scaffold showed significantly higher cell-seeding efficiency (1.8-fold) and metabolic activities (1.5-fold at seven days) than pure PCL with a similar pore size and porosity. These results suggest that the d-ECM-based scaffold is promising as a biomedical substrate to effectively regenerate tissues and that this fabrication method will be very useful for designing biomimetic biomedical scaffolds.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Biotechnology and Bioengineering > Department of Bio-mechatronic Engineering > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/41755)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.