Single monosomy as a relatively better survival factor in acute myeloid leukemia patients with monosomal karyotypeopen access
- Authors
- Jang, JE[Jang, J. E.]; Min, YH[Min, Y. H.]; Yoon, J[Yoon, J.]; Kim, I[Kim, I.]; Lee, JH[Lee, J-H]; Jung, CW[Jung, C. W.]; Shin, HJ[Shin, H-J]; Lee, WS[Lee, W. S.]; Lee, JH[Lee, J. H.]; Hong, DS[Hong, D-S]; Kim, HJ[Kim, H-J]; Kim, HJ[Kim, H-J]; Park, S[Park, S.]; Lee, KH[Lee, K-H]; Jang, JH[Jang, J. H.]; Chung, JS[Chung, J. S.]; Lee, SM[Lee, S. M.]; Park, J[Park, J.]; Park, SK[Park, S. K.]; Ahn, JS[Ahn, J-S]; Min, WS[Min, W-S]; Cheong, JW[Cheong, J-W]
- Issue Date
- Oct-2015
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- BLOOD CANCER JOURNAL, v.5, no.10
- Indexed
- SCIE
SCOPUS
- Journal Title
- BLOOD CANCER JOURNAL
- Volume
- 5
- Number
- 10
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/42947
- DOI
- 10.1038/bcj.2015.84
- ISSN
- 2044-5385
- Abstract
- Monosomal karyotype (MK) defined by either >= 2 autosomal monosomies or single monosomy with at least one additional structural chromosomal abnormality is associated with a dismal prognosis in patients with acute myeloid leukemia (AML). It was detected in 174 of 3041 AML patients in South Korean Registry. A total of 119 patients who had received induction therapy were finally analyzed to evaluate the predictive factors for a positive prognosis. On multivariate analysis, single monosomy, the absence of abn(17p), >= 10% of cells with normal metaphase and the achievement of a complete remission (CR) after induction therapy were significant factors for more favorable outcomes. Especially, single monosomy remained as a significantly independent prognostic factor for superior survival in both patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) in CR and who did not. Allo-HSCT in CR improved overall survival significantly only in patients with a single monosomy. Our results suggest that MK-AML may be biologically different according to the karyotypic subtype and that allo-HSCT in CR should be strongly recommended to patients with a single monosomy. For other patients, more prudent treatment strategies should be examined. Furthermore, the biological mechanism by which a single monosomy influences survival should be investigated.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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