The Photoprotective Effect of S-Methylmethionine Sulfonium in Skinopen access
- Authors
- Kim W.-S.[Kim W.-S.]; Seo H.-M.[Seo H.-M.]; Kim W.-K.[Kim W.-K.]; Choi J.-S.[Choi J.-S.]; Kim I.[Kim I.]; Sung J.-H.[Sung J.-H.]
- Issue Date
- Aug-2015
- Publisher
- MDPI AG
- Keywords
- S-methylmethionine sulfonium; UVB protection; dermal fibroblasts; keratinocyte progenitor cells; erythema
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.16, no.8, pp.17088 - 17100
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 16
- Number
- 8
- Start Page
- 17088
- End Page
- 17100
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/43306
- DOI
- 10.3390/ijms160817088
- ISSN
- 1422-0067
- Abstract
- S-Methylmethionine sulfonium (SMMS) was reported to have wound-healing effects; we therefore have investigated the photoprotective effect of SMMS in the present study. SMMS increased the viability of keratinocyte progenitor cells (KPCs) and human dermal fibroblasts (hDFs) following ultraviolet B (UVB) irradiation, and reduced the UVB-induced apoptosis in these cells. SMMS increased the phosphorylation of extracellular signal-regulated kinases (ERK), and the inhibitor of the mitogen-activated protein kinase pathway significantly decreased the SMMS-induced viability of KPCs and hDFs. In addition, SMMS attenuated the UVB-induced reactive oxygen species (ROS) generation in KPCs and hDFs. SMMS induced the collagen synthesis and reduced the matrix metalloproteinase-1 expression in UVB-irradiated hDFs. In animal studies, application of 5% and 10% SMMS before and after UVB-irradiation significantly decreased the UVB-induced erythema index and depletion of Langerhans cells. In summary, SMMS protects KPCs and hDFs from UVB irradiation, and reduces UVB-induced skin erythema and immune suppression. Therefore, SMMS can be used as a cosmetic raw material, and protect skin from UVB.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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