Development of poly(lactic-co-glycolic acid) microparticles with pH-sensitive drug release behaviors
- Authors
- Lee J.O.[Lee J.O.]; Youn Y.S.[Youn Y.S.]; Lee D.-K.[Lee D.-K.]; Cha K.-H.[Cha K.-H.]; Lee E.S.[Lee E.S.]
- Issue Date
- Apr-2015
- Publisher
- 한국약제학회
- Keywords
- 3-diethylaminopropylated poly(l-lysine); PLGA microparticle; Tiotropium
- Citation
- Journal of Pharmaceutical Investigation, v.45, no.2, pp.151 - 156
- Indexed
- SCOPUS
KCI
- Journal Title
- Journal of Pharmaceutical Investigation
- Volume
- 45
- Number
- 2
- Start Page
- 151
- End Page
- 156
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/44190
- DOI
- 10.1007/s40005-014-0157-9
- ISSN
- 2093-5552
- Abstract
- We developed a novel pH-sensitive microparticle using poly(lactide-co-glycolide) (PLGA) and 3-diethylaminopropylated poly(l-lysine) [poly(Lys-DEAP)] (pKb of DEAP ~6.5). Here, the design of the microparticle takes advantage of the unique pH-sensitive feature of poly(Lys-DEAP) as either a non-ionic characteristic of DEAP moieties at pH 7.4 or an ionic characteristic of DEAP moieties at acidic pH. In particular, the ionized DEAP in PLGA microparticles modulated acidic pH-activated microparticle-destruction and allowed accelerated release of the encapsulated drug content when the pH of the solution was decreased to from 7.4 to 6.8 or 6.0. We believe that this microparticle system is expected to improve the treatment efficacy for lung diseases with chronic respiratory acidosis. © 2014, The Korean Society of Pharmaceutical Sciences and Technology.
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