Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actionsopen access
- Authors
- Yang, Y[Yang, Yanyan]; Lee, J[Lee, Jongsung]; Rhee, MH[Rhee, Man Hee]; Yu, T[Yu, Tao]; Baek, KS[Baek, Kwang-Soo]; Sung, NY[Sung, Nak Yoon]; Kim, Y[Kim, Yong]; Yoon, K[Yoon, Keejung]; Kim, JH[Kim, Ji Hye]; Kwak, YS[Kwak, Yi-Seong]; Hong, S[Hong, Sungyoul]; Kim, JH[Kim, Jong-Hoon]; Cho, JY[Cho, Jae Youl]
- Issue Date
- Jan-2015
- Publisher
- 고려인삼학회
- Keywords
- activating transcription factor 2; anti-inflammatory activity; interferon regulatory transcription factor 3; Korean red ginseng; protopanaxadiol saponin fraction
- Citation
- JOURNAL OF GINSENG RESEARCH, v.39, no.1, pp.61 - 68
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- Volume
- 39
- Number
- 1
- Start Page
- 61
- End Page
- 68
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/45064
- DOI
- 10.1016/j.jgr.2014.06.002
- ISSN
- 1226-8453
- Abstract
- Background: Korean Red Ginseng (KRG) is a representative traditional herbal medicine with many different pharmacological properties including anticancer, anti-atherosclerosis, anti-diabetes, and anti-inflammatory activities. Only a few studies have explored the molecular mechanism of KRG-mediated anti-inflammatory activity. Methods: We investigated the anti-inflammatory mechanisms of the protopanaxadiol saponin fraction (PPD-SF) of KRG using in vitro and in vivo inflammatory models. Results: PPD-SF dose-dependently diminished the release of inflammatory mediators [nitric oxide (NO), tumor necrosis factor-alpha, and prostaglandin E-2], and downregulated the mRNA expression of their corresponding genes (inducible NO synthase, tumor necrosis factor-alpha, and cyclooxygenase-2), without altering cell viability. The PPD-SF-mediated suppression of these events appeared to be regulated by a blockade of p38, c-Jun N-terminal kinase (JNK), and TANK (TRAF family member-associated NF-kappa-B activator)-binding kinase 1 (TBK1), which are linked to the activation of activating transcription factor 2 (ATF2) and interferon regulatory transcription factor 3 (IRF3). Moreover, this fraction also ameliorated HCl/ethanol/-induced gastritis via suppression of phospho-JNK2 levels. Conclusion: These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-. JNK2-, and TANK-binding-kinase-l-linked pathways and their corresponding transcription factors (ATF2 and IRF3). Copyright (C) 2014, The Korean Society of Ginseng. Published by Elsevier. All rights reserved.
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- Appears in
Collections - Biotechnology and Bioengineering > Integrative Biotechnology > 1. Journal Articles
- Biotechnology and Bioengineering > Department of Genetic Engineering > 1. Journal Articles
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