Autocrine stimulation of IL-10 is critical to the enrichment of
IL-10-producing CD40(hi)CD5(+) regulatory B cells in vitro and in vivoopen access
- Authors
- Kim, HS[Kim, Hyuk Soon]; Lee, JH[Lee, Jun Ho]; Han, HD[Han, Hee Dong]; Kim, AR[Kim, A-Ram]; Nam, ST[Nam, Seung Taek]; Kim, HW[Kim, Hyun Woo]; Park, YH[Park, Young Hwan]; Lee, D[Lee, Dajeong]; Lee, MB[Lee, Min Bum]; Park, YM[Park, Yeong Min]; Kim, HS[Kim, Hyung Sik]; Kim, YM[Kim, Young Mi]; You, JC[You, Ji Chang]; Choi, WS[Choi, Wahn Soo]
- Issue Date
- Jan-2015
- Publisher
- 생화학분자생물학회
- Keywords
- Autocrine; CD5; CD40; Interleukin-10; Regulatory B cells
- Citation
- BMB REPORTS, v.48, no.1, pp.54 - U71
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 48
- Number
- 1
- Start Page
- 54
- End Page
- U71
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/45084
- DOI
- 10.5483/BMBRep.2015.48.1.213
- ISSN
- 1976-6696
- Abstract
- IL-10-producing B (Breg) cells regulate various immune responses. However, their phenotype remains unclear. CD40 expression was significantly increased in B cells by LPS, and the Breg cells were also enriched in CD40(hi)CD(5+) B cells. Furthermore, CD40 expression on Breg cells was increased by IL-10, CD40 ligand, and B cell-activating factor, suggesting that CD40(hi) is a common phenotype of Breg cells. LPS-induced CD40 expression was largely suppressed by an anti-IL-10 receptor antibody and in IL-10(-/-)CD(5+) CD19+ B cells. The autocrine effect of IL-10 on the CD40 expression was largely suppressed by an inhibitor of JAK/STAT3. In vivo, the LPS treatment increased the population of CD40(hi)CD(5+) Breg cells in mice. However, the population of CD40(hi)CD(5+) B cells was minimal in IL-10(-/-) mice by LPS. Altogether, our findings show that Breg cells are largely enriched in CD40(hi)CD(5+) B cells and the autocrine effect of IL-10 is critical to the formation of CD40(hi)CD(5+) Breg cells.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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