Possible Association between Serotonin Transporter Gene Polymorphism and Suicide Behavior in Major Depressive Disorderopen access
- Authors
- 이화영[이화영]; 홍진표[홍진표]; 황정아[황정아]; 이헌정[이헌정]; 윤호경[윤호경]; 이분희[이분희]; 김용구[김용구]
- Issue Date
- 2015
- Publisher
- 대한신경정신의학회
- Keywords
- Serotonin transporter; Polymorphism; Haplotype; Suicide; Major depressive disorder
- Citation
- PSYCHIATRY INVESTIGATION, v.12, no.1, pp.136 - 141
- Indexed
- SCIE
SSCI
SCOPUS
KCI
- Journal Title
- PSYCHIATRY INVESTIGATION
- Volume
- 12
- Number
- 1
- Start Page
- 136
- End Page
- 141
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/45803
- DOI
- 10.4306/pi.2015.12.1.136
- ISSN
- 1738-3684
- Abstract
- ObjectiveaaThe serotonin transporter (5-HTT) genes are major candidate genes for modulating the suicidal behavior. We investigated the association between serotonin transporter polymorphisms and suicidal behavior in patients with major depressive disorder (MDD).
MethodsaaSerotonin transporter intron 2 VNTR polymorphism (5-HTTVNTR) and serotonin transporter linked polymorphic region polymorphism (5-HTTLPR) were analyzed in 132 depressed patients with suicidal attempt as well as in 122 normal controls. Hamilton’s 17-item Depression Rating Scale (HDRS), the Risk-Rescue rating system (RRR) and the Lethality Suicide Attempt Rating Scale updated (LSARS-II) were assessed for the depressed patients.
ResultsaaAlthough not statistically significant, a trend was found such that the 10/10 and 10/12 alleles of 5-HTTVNTR were more common in suicidal subjects than in control subjects. Comparing allele frequency, those with a 10 allele or 10 allele carriers were higher in suicidal subjects than in control subjects. No difference was noted in 5-HTTLPR genotypes and haplotype distribution between the suicidal subjects and control subjects. The RRR scores in subjects with the 10/10 5-HTTVNTR genotype or 10 5-HTTVNTR allele were significantly lower than those in subjects with other genotypes.
ConclusionaaThese results show the possibility that 10 allele of 5-HTTVNTR is related to suicidal behavior in the suicidal subjects with MDD and suggest that 12 allele of 5-HTTVNTR might be related to more lethality in the suicidal subjects with MDD.
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