Comparison of 12-month clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion lesions: A multicenter study
- Authors
- Rha, S.-W.[Rha, S.-W.]; Choi, C.U.[Choi, C.U.]; Na, J.O.[Na, J.O.]; Lim, H.E.[Lim, H.E.]; Kim, J.W.[Kim, J.W.]; Kim, E.J.[Kim, E.J.]; Park, C.G.[Park, C.G.]; Seo, H.S.[Seo, H.S.]; Oh, D.J.[Oh, D.J.]; Gwon, H.-C.[Gwon, H.-C.]; Kim, B.-K.[Kim, B.-K.]; Kim, H.-S.[Kim, H.-S.]; Yu, C.W.[Yu, C.W.]; Park, H.S.[Park, H.S.]; Chae, I.-H.[Chae, I.-H.]; Lee, S.-H.[Lee, S.-H.]; Kim, M.H.[Kim, M.H.]; Hur, S.-H.[Hur, S.-H.]; Ahn, Y.-K.[Ahn, Y.-K.]; Jang, Y.[Jang, Y.]
- Issue Date
- 2015
- Keywords
- chronic total occlusion; diabetic; major adverse cardiac events
- Citation
- Coronary Artery Disease, v.26, no.8, pp.699 - 705
- Journal Title
- Coronary Artery Disease
- Volume
- 26
- Number
- 8
- Start Page
- 699
- End Page
- 705
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/48366
- DOI
- 10.1097/MCA.0000000000000304
- Abstract
- Objective This study aimed to compare 1-year clinical outcomes in diabetic and nondiabetic patients with chronic total occlusion (CTO) lesions. Methods A total of 2865 patients (age 62.82 ± 10.64 years; 74.0% men) undergoing percutaneous coronary intervention for CTO were analyzed. The patients were classified as diabetic (n=977) or nondiabetic (n=1888). One-year clinical outcomes were compared between the two groups. Results One year after percutaneous coronary intervention, 241 (8.4%) patients developed major adverse cardiac events (MACEs). Target lesion revascularization (TLR), target vessel revascularization (TVR), TLR-MACEs, and total MACEs were more common in diabetics than in nondiabetics (6.1 vs. 3.9%, P=0.021; 7.2 vs. 4.8%, P=0.023; 7.7 vs. 5.5%, P=0.017; and 10.3 vs. 7.7%, P=0.011; respectively). In multivariate analysis, diabetes mellitus was an independent predictor for 1-year TLR (odds ratio: 2.201, P=0.001) and total MACEs (odds ratio: 1.677, P=0.002). Among diabetic patients, total death, TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs were more common in patients who used insulin than in those who did not (6.1 vs. 1.9%, P=0.018; 11.3 vs. 4.6%, P=0.007; 12.2 vs. 5.9%, P=0.025; 14.8 vs. 5.9%, P=0.003; 16.5 vs. 8.0%, P=0.008; and 17.4 vs. 9.2%, P=0.012, respectively). Insulin use was an independent predictor for total death, 12-month TLR, TVR, TLR-MACEs, TVR-MACEs, and total MACEs. Conclusion This study identified diabetes mellitus as an independent risk factor for 1-year TLR and total MACEs in patients with CTO lesions. © 2015 Wolters Kluwer Health, Inc. All rights reserved.
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