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A new cerebroside from the fruiting bodies of Hericium erinaceus and its applicability to cancer treatment
- Authors
- Lee, S.R.[Lee, S.R.]; Jung, K.[Jung, K.]; Noh, H.J.[Noh, H.J.]; Park, Y.J.[Park, Y.J.]; Lee, H.L.[Lee, H.L.]; Lee, K.R.[Lee, K.R.]; Kang, K.S.[Kang, K.S.]; Kim, K.H.[Kim, K.H.]
- Issue Date
- 2015
- Citation
- Bioorganic and Medicinal Chemistry Letters, v.25, no.24, pp.5712 - 5715
- Journal Title
- Bioorganic and Medicinal Chemistry Letters
- Volume
- 25
- Number
- 24
- Start Page
- 5712
- End Page
- 5715
- Abstract
- A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment. © 2015 Elsevier Ltd.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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