Association Between Nonalcoholic Fatty Liver Disease and Carotid Artery Inflammation Evaluated by 18F-Fluorodeoxyglucose Positron Emission Tomography
- Authors
- Moon S.H.[Moon S.H.]; Noh T.S.[Noh T.S.]; Cho Y.S.[Cho Y.S.]; Hong S.P.[Hong S.P.]; Hyun S.H.[Hyun S.H.]; Choi J.Y.[Choi J.Y.]; Kim B.-T.[Kim B.-T.]; Lee K.-H.[Lee K.-H.]
- Issue Date
- 2015
- Keywords
- nonalcoholic fatty liver disease; atherosclerosis; carotid artery; FDG; PET; CT
- Citation
- Angiology, v.66, no.5, pp.472 - 480
- Journal Title
- Angiology
- Volume
- 66
- Number
- 5
- Start Page
- 472
- End Page
- 480
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/49846
- DOI
- 10.1177/0003319714537872
- Abstract
- We assessed the association between nonalcoholic fatty liver disease (NAFLD) and carotid artery inflammation measured by 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. Participants were 755 consecutive otherwise healthy adult males who underwent a general health screening program. Carotid FDG uptake, represented as maximum target-to-background ratio, was increased with mild (n = 237; 1.61 ± 0.14; P =.033) and moderate NAFLD (n = 145; 1.63 ± 0.16; P =.005) compared with controls (n = 373; 1.58 ± 0.15). In patients aged >50 years, moderate NAFLD was the only independent risk factor for high carotid FDG uptake (odds ratio, 2.12; 95% confidence interval, 1.10-4.07; P =.001). Apparently healthy adult males with NAFLD have elevated carotid FDG uptake as well as increased carotid intima-media thickness, suggesting that they may be at an increased risk of having inflammatory atherosclerotic plaques in the carotid arteries. © The Author(s) 2014.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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