Emphysematous phenotype is an independent predictor for frequent exacerbation of COPD
- Authors
- Oh, YM[Oh, Y-M.]; Sheen, SS[Sheen, S-S]; Park, JH[Park, J. H.]; Jin, UR[Jin, U. R.]; Yoo, JW[Yoo, J-W.]; Seo, JB[Seo, J. B.]; Yoo, KH[Yoo, K. H.]; Lee, JH[Lee, J-H.]; Kim, TH[Kim, T-H.]; Lim, SY[Lim, S. Y.]; Yoon, HI[Yoon, H. I.]; Lee, JS[Lee, J. S.]; Lee, SD[Lee, S-D.]
- Issue Date
- Dec-2014
- Publisher
- INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
- Keywords
- emphysema; frequent exacerbation; COPD
- Citation
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.18, no.12, pp.1407 - 1414
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
- Volume
- 18
- Number
- 12
- Start Page
- 1407
- End Page
- 1414
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/50580
- DOI
- 10.5588/ijtld.14.0205
- ISSN
- 1027-3719
- Abstract
- SETTING: Frequent exacerbation is an important phenotype in chronic obstructive pulmonary disease (COPD), while emphysema is associated with many comorbidities and lung function decline. OBJECTIVE: To investigate unique features of frequent exacerbators and test the hypothesis that emphysematous phenotype is associated with frequent exacerbations of COPD. METHODS: A total of 380 COPD patients were recruited from 16 hospitals in Korea from June 2005 to April 2012 for analysis. We searched for independent predictors of frequent exacerbators in comparison with non-exacerbators. RESULTS: As the severity of emphysema increased, forced expiratory volume in 1 s (FEV1), and FEV1/FVC (forced volume capacity) worsened; hyperinflationary features characterised by higher total lung capacity (TLC) were observed (P < 0.05). Frequent cxacerbators had lower body mass index (BMI), higher St George's Respiratory Questionnaire (SGRQ) scores, higher residual volume (RV)/TLC, more severe airflow limitation (lower FEVi and FEVi/FVC), lower carbon monoxide diffusion capacity, lower serum protein levels and a higher emphysema index than non-exacerbators (P < 0.05). In multivariate analysis, frequent exacerbators were independently associated with a higher emphysema index, lower serum protein levels and higher RV/TLC (P < 0.05). CONCLUSION: Our data show that the severity of emphysema, severe static hyperinflation and serum lower protein levels are independent predictors of frequent exacerbations in COPD patients.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/50580)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.