Role of Radiofrequency Ablation in Patients with Hepatocellular Carcinoma Who Undergo Prior Transarterial Chemoembolization: Long-Term Outcomes and Predictive Factors
- Authors
- Sohn, W[Sohn, Won]; Choi, MS[Choi, Moon Seok]; Cho, JY[Cho, Ju Yeon]; Gwak, GY[Gwak, Geum-Youn]; Paik, YH[Paik, Yong-Han]; Lee, JH[Lee, Joon Hyeok]; Koh, KC[Koh, Kwang Cheol]; Paik, SW[Paik, Seung Woon]; Yoo, BC[Yoo, Byung Chul]
- Issue Date
- Sep-2014
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Carcinoma; hepatocellular; Transarterial chemoembolization; Radiofrequency ablation; Outcome; Recurrence
- Citation
- GUT AND LIVER, v.8, no.5, pp.543 - 551
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- GUT AND LIVER
- Volume
- 8
- Number
- 5
- Start Page
- 543
- End Page
- 551
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/51953
- DOI
- 10.5009/gnl13356
- ISSN
- 1976-2283
- Abstract
- Background/Aims: The role of radiofrequency ablation (RFA) remains uncertain in patients with viable hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). Methods: A total of 101 patients (April 2007 to August 2010) underwent RFA for residual or recurrent HCC after TACE. We analyzed their long-term outcomes and predictive factors. Results: The overall survival rates after RFA were 93.1%, 65.4%, and 61.0% at 1, 3, and 5 years, respectively. Predictive factors for favorable overall survival were Child-Pugh class A (hazard ratio [HR], 3.45; p=0.001), serum cc-fetoprotein (AFP) level <20 ng/mL (HR, 2.90; p=0.02), and recurrent tumors after the last TACE (HR, 3.14; p=0.007). The cumulative recurrence-free survival rate after RFA at 6 months was 50.1%. Predictive factors for early recurrence (within 6 months) were serum AFP level >= 2 ng/mL (HR, 3.02; p<0.001), tumor size >= 30 mm at RFA (HR, 2.90; p=0.005), and nonresponse to the last TACE (HR, 2.13; 0=0.013). Conclusions: Patients with recurrent or residual HCC who undergo prior TACE show a favorable overall survival, although their tumors seem to recur early and frequently. While good liver function, a low serum AFP level, and recurrent tumors were independent predictive factors for a favorable overall survival, poor response to TACE, a high serum AFP level, and large tumors are associated with early recurrence.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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