Impact of donor kidney function and donor age on poor outcome of living-unrelated kidney transplantation (KT) in comparison with living-related KT
- Authors
- Park, KS[Park, Kyung Sun]; Shin, JH[Shin, Jung-ho]; Jang, HR[Jang, Hye Ryoun]; Lee, JE[Lee, Jung Eun]; Huh, WS[Huh, Woo Seong]; Kim, YG[Kim, Yoon Goo]; Oh, HY[Oh, Ha Young]; Kim, DJ[Kim, Dae Joong]
- Issue Date
- Sep-2014
- Publisher
- WILEY-BLACKWELL
- Keywords
- donor estimated glomerular filtration rate; HLA-DR mismatches; Living-unrelated kidney transplantation
- Citation
- CLINICAL TRANSPLANTATION, v.28, no.9, pp.953 - 960
- Indexed
- SCIE
SCOPUS
- Journal Title
- CLINICAL TRANSPLANTATION
- Volume
- 28
- Number
- 9
- Start Page
- 953
- End Page
- 960
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/51955
- DOI
- 10.1111/ctr.12388
- ISSN
- 0902-0063
- Abstract
- Living-unrelated donors (LURD) have been widely used for kidney transplantation (KT). We retrospectively reviewed 779 patients who underwent living-donor KT from 2000 to 2012, to compare outcomes of 264 KT from LURD and 515 from living-related donors (LRD), and to identify risk factors for living KT. Median follow-up was 67months. Mean donor age, total human leukocyte antigen (HLA) mismatches, and HLA-DR mismatches were higher, and mean estimated glomerular filtration rate (eGFR) was lower in LURD. Acute rejection (AR)-free survival (p=0.018) and graft survival (p=0.025) were lower for LURD than LRD, whereas patient survival rate was comparable. Cox regression analysis showed HLA-DR mismatches (OR 1.75 for one mismatch; OR 2.19 for two mismatches), recipient age42yr, and donor age>50yr were significant risk factors for acute rejection. For graft survival, AR and donor eGFR (OR 1.90, p=0.035) were significant. We also identified significant impact of recipient age>50yr and diabetes for patient survival. However, KT from LURD was not a significant risk factor for AR (p=0.368), graft survival (p=0.205), and patient survival (p=0.836). Our data suggest that donor eGFR and donor age are independent risk factors for clinical outcomes of living KT, which can be related with poor outcome of KT from LURD.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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