The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung canceropen access
- Authors
- Kang, MH[Kang, M. H.]; Go, SI[Go, S-I]; Song, HN[Song, H-N]; Lee, A[Lee, A.]; Kim, SH[Kim, S-H]; Kang, JH[Kang, J-H]; Jeong, BK[Jeong, B-K]; Kang, KM[Kang, K. M.]; Ling, H[Ling, H.]; Lee, GW[Lee, G-W]
- Issue Date
- 29-Jul-2014
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; overall survival
- Citation
- BRITISH JOURNAL OF CANCER, v.111, no.3, pp.452 - 460
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRITISH JOURNAL OF CANCER
- Volume
- 111
- Number
- 3
- Start Page
- 452
- End Page
- 460
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/52279
- DOI
- 10.1038/bjc.2014.317
- ISSN
- 0007-0920
- Abstract
- Background: The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are prognostic factors for various types of cancer. In this study, we assessed the association of NLR and PLR with the prognosis of small-cell lung cancer (SCLC) in patients who received the standard treatment. Methods: We retrospectively reviewed patients who were diagnosed with SCLC and treated with platinum-based chemotherapy between July 2006 and October 2013 in Gyeongsang National University Hospital Regional Cancer Center and Changwon Samsung Hospital. Results: In total, 187 patients were evaluated. Compared with low NLR (<4), high NLR (>= 4) at diagnosis was associated with poor performance status, advanced stage, and lower response rate. Median overall survival (OS) and progression-free survival (PFS) were worse in the high-NLR group (high vs low, 11.17 vs 9.20 months, P = 0.019 and 6.90 vs 5.49 months, P = 0.005, respectively). In contrast, PLR at diagnosis was not associated with OS or PFS (P = 0.467 and P = 0.205, respectively). In multivariate analysis, stage, lactate dehydrogenase, and NLR at diagnosis were independent prognostic factors for OS and PFS. Conclusions: NLR is easily measurable and reflects the SCLC prognosis. A future prospective study is warranted to confirm our results.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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