Long- term survival after surgical resection for huge hepatocellular carcinoma: Comparison with transarterial chemoembolization after propensity score matching
- Authors
- Min, YW[Min, Yang Won]; Lee, JH[Lee, Jun Hee]; Gwak, GY[Gwak, Geum-Youn]; Paik, YH[Paik, Yong Han]; Lee, JH[Lee, Joon Hyoek]; Rhee, PL[Rhee, Poong-Lyul]; Koh, KC[Koh, Kwang Cheol]; Paik, SW[Paik, Seung Woon]; Yoo, BC[Yoo, Byung Chul]; Choi, MS[Choi, Moon Seok]
- Issue Date
- May-2014
- Publisher
- WILEY-BLACKWELL
- Keywords
- huge hepatocellular carcinoma; surgical resection; transarterial chemoembolization
- Citation
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, v.29, no.5, pp.1043 - 1048
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Volume
- 29
- Number
- 5
- Start Page
- 1043
- End Page
- 1048
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/53140
- DOI
- 10.1111/jgh.12504
- ISSN
- 0815-9319
- Abstract
- Background and AimsSurgical resection (SR) and transarterial chemoembolization (TACE) have been commonly applied for patients with huge hepatocellular carcinoma (HCC). However, optimal treatment has not been established. MethodsBetween 2000 and 2009, 267 patients with huge HCC (10cm) underwent TACE and 84 underwent SR as the first treatment. Propensity score matching generated a matched cohort composed of 152 patients. We investigated overall survival and possible prognostic factors. ResultsAt baseline, the surgery group showed a tendency to have solitary tumor (72.6% vs 39.3%, P<0.001), less vessel invasion (29.8% vs 51.3%, P<0.001), and unilobar tumor extent (77.4% vs 50.9%, P<0.001) than TACE group. During median follow up of 10 months (range: 0-103), the surgery group showed higher 1-, 3-, and 5-year overall survival rates than TACE group (73.8%, 54.8%, and 39.8% vs 37.8%, 16.3%, and 9.7%, respectively, P<0.001). In the propensity score-matched cohort, baseline characteristics did not differ between the two groups. Surgery group showed higher 1-, 2-, and 3-year overall survival rates than TACE group (69.7%, 58.6%, and 51.7% vs 40.2%, 33.9%, and 18.5%, respectively, P<0.001) during median follow up of 14.5 months (range: 0-103). Multivariate analysis revealed that male (HR 1.90; 95% CI, 1.01-3.58; P=0.048), albumin (HR 0.54; 95% CI, 0.34-0.85; P=0.008), ascites (HR 1.77; 95% CI, 1.02-3.08; P=0.044), and SR (HR 0.44; 95% CI, 0.28-0.70; P=0.001) were the independent prognostic factors associated with survival. ConclusionComparing survival after SR and TACE, we showed that SR would be associated with better outcomes than TACE as the first treatment of huge HCC.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.