Outcomes of acute lymphoblastic leukaemia in adolescent and young adult Korean patients
- Authors
- Kim, YA[Kim, Young Ae]; Ju, HY[Ju, Hee Young]; Park, HJ[Park, Hyeon Jin]; Lee, NY[Lee, Na Young]; Lee, HJ[Lee, Hyun Jeong]; Lee, H[Lee, Hyewon]; Ghang, H[Ghang, Haryeom]
- Issue Date
- Mar-2020
- Publisher
- WILEY
- Keywords
- acute lymphoblastic leukaemia; adolescents; young adults; asparaginase; Treatment outcome
- Citation
- BRITISH JOURNAL OF HAEMATOLOGY, v.188, no.5, pp.740 - 744
- Indexed
- SCIE
SCOPUS
- Journal Title
- BRITISH JOURNAL OF HAEMATOLOGY
- Volume
- 188
- Number
- 5
- Start Page
- 740
- End Page
- 744
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/5351
- DOI
- 10.1111/bjh.16242
- ISSN
- 0007-1048
- Abstract
- This study used Korean national data to investigate the relationship between treatment patterns and outcomes in Korean adolescent and young-adult (AYA) acute lymphoblastic leukaemia (ALL) patients. Chemotherapy incorporating L-asparaginase was considered paediatric-inspired (PI), as opposed to adult protocols. In total, 65 center dot 3% of patients received PI therapy. Five-year overall survival (OS) of PI-treated patients outperformed adult protocols (63 center dot 1% vs. 40 center dot 4%; P < 0 center dot 0001); this trend was maintained within various age subgroups. Younger age, L-asparaginase therapy, and radiotherapy corresponded with superior OS by multivariable analysis. OS tends to improve with PI protocols that include L-asparaginase in AYA ALL, suggesting that therapy protocol is critical in the treatment performance of this group.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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