Expression of Cell Cycle-Related Proteins, p16, p53 and p63 as Important Prognostic Markers in Gallbladder Adenocarcinoma
- Authors
- Kim, K[Kim, Kyungeun]; Kim, DH[Kim, Dong-Hoon]; Chae, SW[Chae, Seoung Wan]; Shin, JH[Shin, Jun-Ho]; Kim, HJ[Kim, Hong Joo]; Do, SI[Do, Sung-Im]; Lee, HJ[Lee, Hyun Joo]; Koo, JH[Koo, Ji Hae]; Pyo, JS[Pyo, Jung-Soo]; Sohn, JH[Sohn, Jin Hee]
- Issue Date
- Apr-2014
- Publisher
- SPRINGER
- Citation
- PATHOLOGY & ONCOLOGY RESEARCH, v.20, no.2, pp.409 - 415
- Indexed
- SCIE
SCOPUS
- Journal Title
- PATHOLOGY & ONCOLOGY RESEARCH
- Volume
- 20
- Number
- 2
- Start Page
- 409
- End Page
- 415
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/53614
- DOI
- 10.1007/s12253-013-9710-5
- ISSN
- 1219-4956
- Abstract
- Gallbladder cancer, the most common biliary tract malignancy, is a highly malignant neoplasm. In the present work, we have analyzed the significance of cell cycle-related proteins to predict prognosis and to provide guidance for optimal therapeutic decision-making in patients with gallbladder adenocarcinoma. The expressions of p16, p21, p27, p53, p63, cyclin D1, bcl-2 and bcl-6 were examined in a tissue microarray constructed from 96 cases of gallbladder adenocarcinoma by immunohistochemistry and correlated with clinicopathologic prognostic factors. Expression of p16 was correlated with a low pT stage, adenoma background and good prognosis. Cases with p63 expression showed a higher T stage, more frequent perineural invasion and poor prognosis when compared to cases without p63 expression. Over-expression of p53 or loss of p53 was associated with poor tumor differentiation, frequent distant metastasis and low disease-specific survival rate. The expressions of p21, p27, bcl-2, bcl-6 and cyclin D1 were not significant prognostic factors for gallbladder adenocarcinoma. These results indicate that p16, p63 and p53 can be used as prognostic markers in gallbladder adenocarcinoma; especially p53 and p63 as poor prognostic markers and p16 as a favorable prognostic marker.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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