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Two New Cytotoxic Spirostane-Steroidal Saponins from the Roots of Bletilla striata
- Authors
- Park, JE[Park, Jong Eel]; Woo, KW[Woo, Kyeong Wan]; Choi, SU[Choi, Sang Un]; Lee, JH[Lee, Je Hyun]; Lee, KR[Lee, Kang Ro]
- Issue Date
- Jan-2014
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- Bletilla striata; Saponins; Spirostane; Steroids; Cytotoxic activity
- Citation
- HELVETICA CHIMICA ACTA, v.97, no.1, pp.56 - 63
- Indexed
- SCIE
SCOPUS
- Journal Title
- HELVETICA CHIMICA ACTA
- Volume
- 97
- Number
- 1
- Start Page
- 56
- End Page
- 63
- ISSN
- 0018-019X
- Abstract
- Two new spirostane-steroidal saponins, bletilnoside A (1) and bletilnoside B (2), together with five known compounds, 3-7, were isolated from the roots of Bletilla striata (Thunb.) Reichb. F. The structures of the new compounds were determined based on their 1D- and 2D-NMR spectral data. The isolated compounds 1-7 were tested for cytotoxicity against four human tumor cells (A549, SK-OV-3, SK-MEL-2, and HCT15) in vitro using a sulforhodamin B bioassay, and compounds 1, 2, and 5 showed significant cytotoxicities against all tested tumor cell lines with IC50 values ranging from 3.98 +/- 0.16 to 12.10 +/- 0.40 mu M.
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