Fucoidan Prevents High-Fat Diet-Induced Obesity in Animals by Suppression of Fat Accumulation
- Authors
- Kim, MJ[Kim, Mi-Ja]; Jeon, J[Jeon, Joseph]; Lee, JS[Lee, Jin-Sil]
- Issue Date
- Jan-2014
- Publisher
- WILEY-BLACKWELL
- Keywords
- fucoidan; steatosis; fat accumulation; antiobesity
- Citation
- PHYTOTHERAPY RESEARCH, v.28, no.1, pp.137 - 143
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 28
- Number
- 1
- Start Page
- 137
- End Page
- 143
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/54324
- DOI
- 10.1002/ptr.4965
- ISSN
- 0951-418X
- Abstract
- This study examines the antiobesity effects of fucoidan in an animal model of diet-induced obesity. Mice were fed a standard diet or high-fat diet (HFD) for 5weeks. After that, the mice were divided into four experimental groups, with 10 mice per group, including a standard diet group, HFD group, HFD containing 1% fucoidan (HFD+FUCO 1%) group and HFD containing 2% fucoidan (HFD+FUCO 2%) group. The fucoidan supplementation group had significantly decreased body-weight gain, food efficiency ratio and relative liver and epididymal fat mass compared with the HFD group. The mice supplemented with fucoidan showed significantly reduced triglyceride, total cholesterol and low-density lipoprotein levels in the plasma. Liver steatosis induced by the HFD improved in the fucoidan-supplemented group. Furthermore, fucoidan affected the down-regulation expression patterns of epididymal adipose tissue genes such as peroxisome proliferator-activated receptor , adipose-specific fatty acid binding protein and acetyl CoA carboxylase. Therefore, fucoidan may be considered for use in improving obesity. Copyright (c) 2013 John Wiley & Sons, Ltd.
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Collections - Science > Department of Biological Science > 1. Journal Articles
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