Memory-enhancing effects of 7,3 ',4 '-trihydroxyisoflavone by regulation of cholinergic function and BDNF signaling pathway in mice
- Authors
- Kim, Seon-Kyung; Ko, Yong-Hyun; Lee, Seok-Yong; Jang, Choon-Gon
- Issue Date
- Mar-2020
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- 7,3 ',4 '-Trihydroxyisoflavone; Cognition; Scopolamine; Cholinergic function; Brain-derived neurotrophic factor; Alzheimer's disease
- Citation
- FOOD AND CHEMICAL TOXICOLOGY, v.137
- Indexed
- SCIE
SCOPUS
- Journal Title
- FOOD AND CHEMICAL TOXICOLOGY
- Volume
- 137
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/5476
- DOI
- 10.1016/j.fct.2020.111160
- ISSN
- 0278-6915
1873-6351
- Abstract
- 7,3',4'-Trihydroxyisoflavone (THIF) is a secondary metabolite derived from daidzein and is abundantly present in soybeans. Daidzein and 7,3',4'-THIF exhibit several pharmacological activities, including antioxidant and anti-atopic properties. However, the effects of 7,3',4'-THIF on cognitive function have not been fully investigated. Here, we evaluated the effects of 7,3',4'-THIF on memory using Y-maze and passive avoidance tests. The positive control groups were given donepezil (5 mg/kg, p.o.) or piracetam (200 mg/kg, i.p.) and the treated groups were given 7,3',4'-THIF (0.25, 0.5 and 1 mg/kg, p.o.). 7,3',4'-THIF at 1 mg/kg and donepezil at 5 mg/kg effectively ameliorated memory impairments induced by scopolamine (0.5 mg/kg, i.p.) in mice. In addition, 7,3',4'-THIF at 1 mg/kg and piracetam at 200 mg/kg significantly enhanced memory in intact mice. To examine the underlying mechanisms of 7,3',4'-THIF on cognition following behavioral experiments, biochemical tests were performed in the whole hippocampus. 7,3',4'-THIF (1 mg/kg, p.o.) significantly recovered scopolamine-induced cholinergic impairments. Moreover, brain-derived neurotrophic factor (BDNF), postsynaptic density protein-95 (PSD-95), and synaptophysin, along with phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) and cAMP response element binding (CREB), were significantly increased by 7,3',4'-THIF (1 mg/kg, p.o.). Our findings indicate that 7,3',4'-THIF improves cognitive function by regulating cholinergic system and BDNF signaling.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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