Age Is the Strongest Effector for the Relationship between Estimated Glomerular Filtration Rate and Coronary Artery Calcification in Apparently Healthy Korean Adults
- Authors
- 채현범[채현범]; 이신영[이신영]; 김남희[김남희]; 한기중[한기중]; 이태훈[이태훈]; 장철민[장철민]; 유경모[유경모]; 박해정[박해정]; 이민경[이민경]; 전원선[전원선]; 박세은[박세은]; 문희수[문희수]; 박철영[박철영]; 이원영[이원영]; 오기원[오기원]; 박성우[박성우]; 이은정[이은정]
- Issue Date
- 2014
- Publisher
- 대한내분비학회
- Keywords
- Coronary artery calcification; Glomerular filtration rate; Renal insufficiency; chronic
- Citation
- Endocrinology and Metabolism, v.29, no.3, pp.312 - 319
- Indexed
- SCOPUS
KCI
- Journal Title
- Endocrinology and Metabolism
- Volume
- 29
- Number
- 3
- Start Page
- 312
- End Page
- 319
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/55018
- ISSN
- 2093-596X
- Abstract
- Background: Chronic kidney disease (CKD) is considered one of the most common risk factors for cardiovascular disease. Coronary artery calcification (CAC) is a potential mechanism that explains the association between renal function and cardiovascular mortality. We aimed to evaluate the association between renal function and CAC in apparently healthy Korean subjects.
Methods: A total of 23,617 participants in a health-screening program at Kangbuk Samsung Hospital were included in the study. Estimated glomerular filtration rate (eGFR) was assessed using the Cockcroft-Gault equation. Coronary artery calcium score (CACS) was measured via multidetector computed tomography. Subjects were divided into three groups according to the CKD Staging system with eGFR grade: stage 1, eGFR ≥90 mL/min/1.73 m2; stage 2, eGFR 60 to 89 mL/min/1.73 m2; and stage 3, eGFR 30 to 59 mL/min/1.73 m2.
Results: The mean age of the participants was 41.4 years and the mean eGFR was 103.6±21.7 mL/min/1.73 m2. Hypertension and diabetes were noted in 43.7% and 5.5% of the participants, respectively. eGFR showed a weakly negative but significant association with CACS in bivariate correlation analysis (r=–0.076, P<0.01). Mean CACS significantly increased from CKD stage 1 to 3. The proportion of subjects who had CAC significantly increased from CKD stage 1 to 3. Although the odds ratio for CAC significantly increased from stage 1 to 3 after adjustment for confounding factors, this significance was reversed when age was included in the model.
Conclusion: In early CKD, renal function negatively correlated with the degree of CAC in Korean subjects. Age was the strongest effector for this association.
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