21-O-Angeloyltheasapogenol E3, a Novel Triterpenoid Saponin from the Seeds of Tea Plants, Inhibits Macrophage-Mediated Inflammatory Responses in a NF-kappa B-Dependent Manneropen access
- Authors
- Yang, WS[Yang, Woo Seok]; Ko, J[Ko, Jaeyoung]; Kim, E[Kim, Eunji]; Kim, JH[Kim, Ji Hye]; Park, JG[Park, Jae Gwang]; Sung, NY[Sung, Nak Yoon]; Kim, HG[Kim, Han Gyung]; Yang, S[Yang, Sungjae]; Rho, HS[Rho, Ho Sik]; Hong, YD[Hong, Yong Deog]; Shin, SS[Shin, Song Seok]; Cho, JY[Cho, Jae Youl]
- Issue Date
- 2014
- Publisher
- HINDAWI PUBLISHING CORPORATION
- Citation
- MEDIATORS OF INFLAMMATION
- Indexed
- SCIE
SCOPUS
- Journal Title
- MEDIATORS OF INFLAMMATION
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/57218
- DOI
- 10.1155/2014/658351
- ISSN
- 0962-9351
- Abstract
- 21-O-Angeloyltheasapogenol E3 (ATS-E3) is a triterpenoid saponin recently isolated from the seeds of the tea tree Camellia sinensis (L.) O. Kuntze. ATS-E3 has several beneficial properties including anti-inflammatory, antidiabetic, antiatherosclerotic, and anticancer effects. Unlike other phenolic compounds isolated from tea plants, there are no studies reporting the pharmacological action of ATS-E3. In this study, we therefore aimed to explore the cellular and molecular inhibitory activities of ATS-E3 in macrophage-mediated inflammatory responses. ATS-E3 remarkably diminished cellular responses of macrophages such as FITC-dextran-induced phagocytic uptake, sodium nitroprusside- (SNP-) induced radical generation, and LPS-induced nitric oxide (NO) production. Analysis of its molecular activity showed that this compound significantly suppressed the expression of inducible NO synthase (iNOS), nuclear translocation of nuclear factor- (NF-) kappa B subunits (p50 and p65), phosphorylation of inhibitor of kappa B kinase (IKK), and the enzyme activity of AKT1. Taken together, the novel triterpenoid saponin compound ATS-E3 contributes to the beneficial effects of tea plants by exerting anti-inflammatory and antioxidative activities in an AKT/IKK/NF-kappa B-dependent manner.
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- Appears in
Collections - Biotechnology and Bioengineering > Integrative Biotechnology > 1. Journal Articles
- Biotechnology and Bioengineering > Department of Genetic Engineering > 1. Journal Articles
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