Hemodynamic changes during continuous infusion of bupivacaine: Is early detection of bupivacaine toxicity possible?
- Authors
- Cho M.S.[Cho M.S.]; Kim W.H.[Kim W.H.]; Shim H.S.[Shim H.S.]; Shin I.-W.[Shin I.-W.]
- Issue Date
- 2014
- Keywords
- Bupivacaine; Cardiotoxicity; Hemodynamic function; Intralipid; Left ventricular systolic pressure
- Citation
- Experimental and Clinical Cardiology, v.20, no.6, pp.4252 - 4262
- Indexed
- SCIE
SCOPUS
- Journal Title
- Experimental and Clinical Cardiology
- Volume
- 20
- Number
- 6
- Start Page
- 4252
- End Page
- 4262
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/58014
- ISSN
- 1205-6626
- Abstract
- Objective: To investigate the hemodynamic effect of intravenous infusion of bupivacaine and examine the possibility of early detection of cardiotoxicity and preventing cardiac arrest in a rat model. Methods: Each experimental group was injected with prepared drugs and hemodynamic function was recorded. First, bupivacaine was infused continuously at a rate of 2 mg/kg/min. In the second experiment, when the left ventricular systolic pressure (LVSP) reached a maximal value during bupivacaine continuous infusion at 2 mg/kg/min, 20% Intralipid® was given as a 3 ml/kg bolus and continued as a 0.3 ml/kg/min infusion. In the third experiment, when the left ventricle reached maximal contracture during bupivacaine infusion at 2 mg/kg/min, the infusion was stopped. Results: Intravenous infusion of bupivacaine has biphasic hemodynamic effects with an initial increase in LVSP and subsequent cardiovascular collapse. Continuous infusion of bupivacaine induced cardiovascular collapse despite administration of Intralipid® after maximum LVSP was reached. When bupivacaine infusion was discontinued after reaching the maximum LVSP, hemodynamic function was maintained without cardiovascular collapse. Conclusion: Intravenous bupivacaine infusion increased the LVSP before cardiovascular collapse. Cardiovascular collapse can be prevented by close observation of hemodynamics and promptly discontinuing infusion of bupivacaine.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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