Association between Plasma Levels of Plasminogen Activator Inhibitor-1 and Colorectal Neoplasms
- Authors
- Kim, ER[Kim, Eun Ran]; Yang, MH[Yang, Mun Hee]; Lim, YJ[Lim, Yeun Jung]; Lee, JH[Lee, Jin Hee]; Chang, DK[Chang, Dong Kyung]; Kim, YH[Kim, Young-Ho]; Son, HJ[Son, Hee Jung]; Kim, JJ[Kim, Jae J.]; Rhee, JC[Rhee, Jong Chul]; Kim, JY[Kim, Jin Yong]
- Issue Date
- Sep-2013
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Citation
- GUT AND LIVER, v.7, no.5, pp.519 - 523
- Indexed
- SCIE
SCOPUS
KCI
OTHER
- Journal Title
- GUT AND LIVER
- Volume
- 7
- Number
- 5
- Start Page
- 519
- End Page
- 523
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/59526
- DOI
- 10.5009/gnl.2013.7.5.519
- ISSN
- 1976-2283
- Abstract
- Background/Aims: Plasminogen activator inhibitor-1 (PAI-1) is important for tumor growth, Invasion, and metastasis. In this study, we investigated the relationship between plasma levels of PAI-1 and colorectal adenomas. Methods: We reviewed the medical records of 3,136 subjects who underwent colonoscopy as a screening exam. The subjects were classified into a case group with adenomas (n=990) and a control group (n=2,146). Plasma PAI-1 levels were categorized into three groups based on tertile. Results: The plasma levels of PAI-1 were significantly higher in adenoma cases than in controls (p=0.023). The prevalence of colorectal adenomas increased significantly with increasing levels of PAI-1 (p=0.038). In the adenoma group, advanced pathologic features, size, and number of adenomas did not differ among the three groups based on tertiles for plasma PAI-1 levels. Using multivariate analysis, we found that plasma level of PAI-1 was not associated with the risk of colorectal adenomas (p=0.675). Adjusted odds ratios for colorectal adenomas according to increasing plasma levels of PAI-1 were 0.980 (95% confidence interval [CI], 0.768 to 1.251) for the second-highest plasma level and 1.091 (95% CI, 0.898 to 1.326) for the highest level, compared with the lowest levels. Conclusions: These results suggest that elevated plasma PAI-1 levels are not associated with the risk of colorectal neoplasms.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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