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Clinical characteristics of patients with tuberculosis-destroyed lung
- Authors
- Rhee, CK[Rhee, C. K.]; Yoo, KH[Yoo, K. H.]; Lee, JH[Lee, J. H.]; Park, MJ[Park, M. J.]; Kim, WJ[Kim, W. J.]; Park, YB[Park, Y. B.]; Hwang, YI[Hwang, Y. I.]; Kim, YS[Kim, Y. S.]; Jung, JY[Jung, J. Y.]; Moon, JY[Moon, J. Y.]; Rhee, YK[Rhee, Y. K.]; Park, HK[Park, H. K.]; Lim, JH[Lim, J. H.]; Park, HY[Park, H. Y.]; Lee, SW[Lee, S. W.]; Kim, YH[Kim, Y. H.]; Lee, SH[Lee, S. H.]; Yoon, HK[Yoon, H. K.]; Kim, JW[Kim, J. W.]; Kim, JS[Kim, J. S.]; Kim, YK[Kim, Y. K.]; Oh, YM[Oh, Y. M.]; Lee, SD[Lee, S. D.]; Kim, HJ[Kim, H. J.]
- Issue Date
- Jan-2013
- Publisher
- INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A
- Keywords
- tuberculosis-destroyed lung; chronic obstructive p
- Citation
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.17, no.1, pp.67 - 75
- Indexed
- SCIE
SCOPUS
- Volume
- 17
- Number
- 1
- Start Page
- 67
- End Page
- 75
- ISSN
- 1027-3719
- Abstract
- SETTING: Multicentre study. OBJECTIVE: To define the clinical characteristics of patients with tuberculosis (TB) destroyed lung due to past TB. DESIGN: We reviewed patients with TB-destroyed lung between May 2005 and June 2011. RESULTS: A total of 595 patients from 21 hospitals were enrolled. The mean age was 65.63 +/- 0.47 (mean +/- standard error); 60.5% were male. The mean number of lobes involved was 2.59 +/- 0.05. Pleural thickening was observed in 54.1% of the patients. Mean forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), FEV1/FVC, bronchodilator response and number of exacerbations per year were respectively 2.06 +/- 0.03 1 (61.26% +/- 0.79), 1.16 +/- 0.02 1 (49.05% +/- 0.84), 58.03% +/- 0.70, 5.70% +/- 0.34, and 0.40 +/- 0.04. The number of lobes involved was significantly correlated with FVC and FEV1, and with the number of exacerbations per year. Use of long-acting muscarinic antagonists or long-acting beta-2 agonists plus inhaled corticosteroids resulted in bronchodilatory effects. Multivariable regression analysis showed that age, initial FEV1 (%) and number of exacerbations during follow-up were independent factors affecting change in FEV1. CONCLUSION: Decreased lung function with exacerbation, and progressive decline of FEV1 were observed in patients with TB-destroyed lung.
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