Dielectrophoretic concentration of low-abundance nanoparticles using a nanostructured tip
- Authors
- Yeo, WH[Yeo, Woon-Hong]; Kopacz, AM[Kopacz, Adrian M.]; Kim, JH[Kim, Jong-Hoon]; Chen, XQ[Chen, Xinqi]; Wu, JS[Wu, Jinsong]; Gao, DY[Gao, Dayong]; Lee, KH[Lee, Kyong-Hoon]; Liu, WK[Liu, Wing-Kam]; Chung, JH[Chung, Jae-Hyun]
- Issue Date
- 7-Dec-2012
- Publisher
- IOP PUBLISHING LTD
- Citation
- NANOTECHNOLOGY, v.23, no.48
- Indexed
- SCIE
SCOPUS
- Journal Title
- NANOTECHNOLOGY
- Volume
- 23
- Number
- 48
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/63313
- DOI
- 10.1088/0957-4484/23/48/485707
- ISSN
- 0957-4484
- Abstract
- Electric field-induced concentration has the potential for application in highly sensitive detection of nanoparticles (NPs) for disease diagnosis and drug discovery. Conventional two-dimensional planar electrodes, however, have shown limited sensitivity in NP concentration. In this paper, the dielectrophoretic (DEP) concentration of low-abundance NPs is studied using a nanostructured tip where a high electric field of 3 x 10(7) V m(-1) is generated. In experimental studies, individual 2, 10, and 100 nm Au NPs are concentrated to a nanotip using DEP concentration and are detected by scanning transmission and scanning electron microscopes. The DEP force on Au NPs near the end of a nanotip is computed according to the distance, and then compared with Brownian motion-induced force. The computational study shows qualitative agreement with the experimental results. When the experimental conditions for DEP concentration are optimized for 8 nm-long oligonucleotides, the sensitivity of a nanotip is 10 aM (10 attomolar; nine copies in a 1.5 mu l sample volume). This DEP concentrator using a nanotip can be used for molecular detection without amplification.
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- Appears in
Collections - Engineering > School of Mechanical Engineering > 1. Journal Articles
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