5-HT1A receptor binding in the dorsal raphe nucleus is implicated in the anxiolytic-like effects of Cinnamomum cassia
- Authors
- Jung, YH[Jung, Yang-Hee]; Kwon, SH[Kwon, Seung-Hwan]; Hong, SI[Hong, Sa-Ik]; Lee, SO[Lee, Sung-Ok]; Kim, SY[Kim, Sun-Yeou]; Lee, SY[Lee, Seok-Yong]; Jang, CG[Jang, Choon-Gon]
- Issue Date
- Dec-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Receptor binding autoradiography; 5-HT1A receptor
- Citation
- PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, v.103, no.2, pp.367 - 372
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
- Volume
- 103
- Number
- 2
- Start Page
- 367
- End Page
- 372
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/63326
- DOI
- 10.1016/j.pbb.2012.09.004
- ISSN
- 0091-3057
- Abstract
- Previously we reported that the 50% EtOH extract of Cinnamomum cassia (C. cassia) possesses anxiolytic-like activity in the mouse elevated plus maze (EPM) test. This activity was blocked by the 5-HT1A receptor antagonist, WAY 100635. Therefore, in order to investigate the effect of C. cassia on 5-HT1A receptor binding, quantitative autoradiography of 5-HT1A receptors was carried out in brains of mice treated acutely and repeatedly with C. cassia. Binding of [H-3]8-OH-DPAT to the 5-HT1A receptor was investigated in the mouse brain. After a single treatment of C. cassia (750 mg/kg, p.o.), [H-3]8-OH-DPAT binding showed a significant increase in the dorsal raphe nucleus (DRN). After repeated treatment with C. cassia (100 mg/kg, once a day for 5 days. p.o.), [H-3]8-OH-DPAT binding showed no significant change in any brain region. Taken together, the anxiolytic-like effect of the 50% EtOH extract of C. cassia might be mediated by region specific change of 5-HT1A receptors in the dorsal raphe nucleus. (C) 2012 Published by Elsevier Inc.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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