Effect of saikosaponin A on maintenance of intravenous morphine self-administration
- Authors
- Yoon, SS[Yoon, Seong Shoon]; Kim, HS[Kim, Hey Soo]; Cho, HY[Cho, Hea-Young]; Yun, J[Yun, Jaesuk]; Chung, EY[Chung, Eun Yong]; Jang, CG[Jang, Choon-Gon]; Kim, KJ[Kim, Kwang Joong]; Yang, CH[Yang, Chae Ha]
- Issue Date
- 31-Oct-2012
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- Morphine; Self-administration; Saikosaponin A; GAB
- Citation
- NEUROSCIENCE LETTERS, v.529, no.1, pp.97 - 101
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROSCIENCE LETTERS
- Volume
- 529
- Number
- 1
- Start Page
- 97
- End Page
- 101
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/63858
- DOI
- 10.1016/j.neulet.2012.08.075
- ISSN
- 0304-3940
- Abstract
- In this study, we investigated the effects of saikosaponin A (SSA), a major compound of Bupleurum falcatum L, on morphine self-administration behavior. Male Sprague-Dawley rats were trained to self-administer intravenous morphine (0.1 mg/kg per injection over 5 s) during daily 1-h sessions under a fixed-ratio 1 schedule. Rats were pretreated with SSA (0.25, 0.5, 1.0 mg/kg) by intraperitoneal injection 30 min prior to the start of the test session. Results demonstrated that pretreatment with SSA reduced morphine-maintained responding dose-dependently. Additionally, SSA inhibition of morphine-reinforced behavior was blocked by the selective GABA(B) receptor antagonist (2S)(+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911), but not the selective GABA(A) receptor antagonist bicuculline. Together, these results suggest that SSA may effectively suppress morphine-reinforced behavior by activating GABA(B) receptors. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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