Comparison of outcomes between radical hysterectomy followed by tailored adjuvant therapy versus primary chemoradiation therapy in IB2 and IIA2 cervical cancer
- Authors
- Park, JY[Park, Jeong-Yeol]; Kim, DY[Kim, Dae-Yeon]; Kim, JH[Kim, Jong-Hyeok]; Kim, YM[Kim, Yong-Man]; Kim, YT[Kim, Young-Tak]; Kim, YS[Kim, Young-Seok]; Kim, HJ[Kim, Ha Jeong]; Lee, JW[Lee, Jeong-Won]; Kim, BG[Kim, Byoung-Gie]; Bae, DS[Bae, Duk-Soo]; Huh, SJ[Huh, Seung Jae]; Nam, JH[Nam, Joo-Hyun]
- Issue Date
- Oct-2012
- Publisher
- KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY
- Keywords
- Bulky early-stage cervical cancer; Chemoradiation
- Citation
- JOURNAL OF GYNECOLOGIC ONCOLOGY, v.23, no.4, pp.226 - 234
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF GYNECOLOGIC ONCOLOGY
- Volume
- 23
- Number
- 4
- Start Page
- 226
- End Page
- 234
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/64161
- DOI
- 10.3802/jgo.2012.23.4.226
- ISSN
- 2005-0380
- Abstract
- Objective: To compare survival outcomes and treatment-related morbidities between radical hysterectomy (RH) and primary chemoradiation therapy (CRT) in patients with bulky early-stage cervical cancer. Methods: We selected 215 patients with stage IB2 and IIA2 cervical cancer (tumor diameter > 4 cm on magnetic resonance imaging) who underwent RH followed by tailored adjuvant therapy (n=147) or primary CRT (n=68) at two tertiary referral centers between 2001 and 2010. Results: About twenty nine percent of patients were cured by RH alone and these patients experienced the best survival outcomes with the lowest morbidity rates. After the median follow-up times of 40 months, 27 RH (18.4%) and 20 CRT (29.4%) patients had recurrence (p=0.068) and 23 (15.6%) and 17 (25%) patients died of disease (p=0.101). The 5-year progression-free survival were 77% and 66% (p=0.047), and the 5-year overall survival were 78% and 67% (p=0.048) after RH and primary CRT, respectively. In multivariate analysis, patients who received primary CRT was at higher risk for tumor recurrence (odds ratio [OR], 2.26; 95% confidence interval [Cl], 1.24 to 4.14; p=0.008) and death (OR, 3.02; 95% Cl, 1.53 to 5.98; p=0.001) than those who received RH. Grade 3-4, early (17% vs. 30.9%, p=0.021) and late (1.4% vs. 8.8%, p=0.007) complications were significantly less frequent after RH than primary CRT. Conclusion: Thirty percent of patients were cured by RH alone. A treatment outcome was better in this retrospective study in terms of morbidity and survival. Randomized trials are needed to confirm this result.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.