Photodynamic therapy using glycol chitosan grafted fullerenes
- Authors
- Kwag, DS[Kwag, Dong Sup]; Oh, NM[Oh, Nam Muk]; Oh, YT[Oh, Young Taik]; Oh, KT[Oh, Kyung Taek]; Youn, YS[Youn, Yu Seok]; Lee, ES[Lee, Eun Seong]
- Issue Date
- 15-Jul-2012
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- Fullerene conjugates; Glycol chitosan; Photodynami
- Citation
- INTERNATIONAL JOURNAL OF PHARMACEUTICS, v.431, no.1-2, pp.204 - 209
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Volume
- 431
- Number
- 1-2
- Start Page
- 204
- End Page
- 209
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/64815
- DOI
- 10.1016/j.ijpharm.2012.04.038
- ISSN
- 0378-5173
- Abstract
- Glycol chitosan (GC)-grafted fullerene (GC-g-C-60) conjugates were developed for use in photodynamic therapy of tumor cells. GC-g-C-60 was synthesized in anhydrous benzene/dimethylsulfoxide (DMSO) co-solvent via the chemical conjugation of free amine groups of GC to C=C double bonds of C-60. The GC-g-C-60 with 5 x 10(-4) C-60 molecules per one repeating unit of GC was soluble in water. As C-60 molecules conjugated to GC increased to 0.16 molecules per one repeating unit of GC, GC-g-C-60 started to form supramolecular assemblies (similar to 30 nm) stabilized in phosphate buffer saline (PBS, 150 mM, pH 7.4). Upon 670 nm light illumination, photo-responsive properties of GC-g-C-60 allowed tremendous singlet oxygen generation in tumor cells for super phototoxicity. GC-g-C-60 also showed highly increased tumor accumulation ability for in vivo tumor of KB tumor-bearing nude mice. It is expected that our GC-g-C-60 conjugate may be a good candidate for in vivo photodynamic therapy in various malignant tumor cells. (C) 2012 Elsevier B.V. All rights reserved.
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Collections - Pharmacy > Department of Pharmacy > 1. Journal Articles
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