Comparison of Desflurane and Sevoflurane Anaesthesia in Relation to the Risk of Vagally Mediated Reflex Bradycardia during Gastrectomy
- Authors
- Joo, Y[Joo, Y.]; Cho, EA[Cho, E-A]; Kim, DK[Kim, D-K]; Shin, BS[Shin, B-S]
- Issue Date
- Jul-2012
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- DESFLURANE; SEVOFLURANE; ANAESTHETICS; GASTRECTOMY
- Citation
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, v.40, no.4, pp.1492 - 1498
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Volume
- 40
- Number
- 4
- Start Page
- 1492
- End Page
- 1498
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/65047
- ISSN
- 0300-0605
- Abstract
- OBJECTIVE: This study compared the risk of clinically significant reflex bradycardia during anaesthesia with sevoflurane or desflurane in patients undergoing gastrectomy. METHODS: In this randomized prospective study, 100 patients undergoing gastrectomy were assigned to receive sevoflurane (n = 50) or desflurane (n = 50) anaesthesia. No anticholinergic prophylaxis was administered. Symptomatic reflex bradycardia was defined as a sudden decrease in heart rate to < 50 beats/min, or a decrease to 50 - 59 beats/min if associated with a systolic arterial pressure of <=. 70 mmHg in response to surgical manoeuvres. If reflex bradycardia developed, atropine or ephedrine were administered according to a predefined treatment protocol. RESULTS: Data from 85 patients were available for analysis. The proportion of patients with symptomatic reflex bradycardia in the sevoflurane and desflurane groups was similar (69.0% versus 55.8%, respectively) and both groups required a similar amount of atropine and/or ephedrine. CONCLUSIONS: Clinically significant reflex bradycardia occurred with a relatively high frequency during gastrectomy. Although desflurane is associated with sympathetic activation, it did not provide a protective effect against vagally mediated reflex bradycardia during gastrectomy compared with sevoflurane.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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