Serial CT Findings of Mycobacterium massiliense Pulmonary Disease Compared with Mycobacterium abscessus Disease after Treatment with Antibiotic Therapy
- Authors
- Kim, HS[Kim, Hyun Su]; Lee, KS[Lee, Kyung Soo]; Koh, WJ[Koh, Won-Jung]; Jeon, K[Jeon, Kyeongman]; Lee, EJ[Lee, Eun Ju]; Kang, H[Kang, Hee]; Ahn, J[Ahn, Joonghyun]
- Issue Date
- Apr-2012
- Publisher
- RADIOLOGICAL SOC NORTH AMERICA
- Citation
- RADIOLOGY, v.263, no.1, pp.260 - 270
- Indexed
- SCIE
SCOPUS
- Journal Title
- RADIOLOGY
- Volume
- 263
- Number
- 1
- Start Page
- 260
- End Page
- 270
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/65958
- DOI
- 10.1148/radiol.12111374
- ISSN
- 0033-8419
- Abstract
- Purpose: To present the serial computed tomographic (CT) findings of lung abnormalities in Mycobacterium massiliense pulmonary disease compared with those in Mycobacterium abscessus disease. Materials and Methods: The institutional review board approved this retrospective study and waived informed consent. Serial chest CT scans of M massiliense (n = 34) and M abscessus (n = 24) pulmonary diseases were retrospectively reviewed. Patients were treated with clarithromycin- containing combination antibiotics regimen, and sputum examinations were performed regularly. CT scans were obtained at the beginning of antibiotic therapy, at the end of 4-week hospitalization, and at the time of 12-month antibiotic therapy. Results: All patients with M massiliense disease had sputum conversion during treatment, whereas 50% of patients with M abscessus disease had sputum conversion. The most common CT findings of M massiliense disease at presentation were cellular bronchiolitis (n = 34, 100%), bronchiectasis (n = 34, 100%), consolidation (n = 33, 97%), nodules (n = 32, 94%), and cavities (n = 15, 44%). These findings were similar in M abscessus disease. Thirty (88%) patients with M massiliense disease had decrease in overall CT score at 12-month therapy, whereas only eight (33%) patients with M abscessus disease had a decrease (P < .0001). Improvement was noticeable in cellular bronchiolitis and cavity in M massiliense disease. Conclusion: Common CT findings of M massiliense diseases overlap with those of M abscessus disease. However, responses to antibiotic treatment are much different; in M massiliense disease, negative sputum conversion is accomplished in all patients and serial CT scans show improvement in most patients. (c) RSNA, 2012
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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