Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Young Children with Atypical Teratoid/Rhabdoid Tumor of the Central Nervous Systemopen access
- Authors
- Park, ES[Park, Eun Sil]; Sung, KW[Sung, Ki Woong]; Baek, HJ[Baek, Hee Jo]; Park, KD[Park, Kyung Duk]; Park, HJ[Park, Hyeon Jin]; Won, SC[Won, Sung Chul]; Lim, DH[Lim, Do Hoon]; Kim, HS[Kim, Heung Sik]
- Issue Date
- Feb-2012
- Publisher
- KOREAN ACAD MEDICAL SCIENCES
- Citation
- JOURNAL OF KOREAN MEDICAL SCIENCE, v.27, no.2, pp.135 - 140
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF KOREAN MEDICAL SCIENCE
- Volume
- 27
- Number
- 2
- Start Page
- 135
- End Page
- 140
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/66560
- DOI
- 10.3346/jkms.2012.27.2.135
- ISSN
- 1011-8934
- Abstract
- The feasibility and effectiveness of tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) were evaluated in children younger than 3 yr of age with atypical teratoid/rhabdoid tumors (ATRT). Tandem HDCT/autoSCT was administered following six cycles of induction chemotherapy. Radiotherapy (RT) was administered if the tumor relapsed or progressed, otherwise, it was administered after 3 yr of age. Tumors relapsed or progressed during induction chemotherapy in 5 of 9 patients enrolled; 3 of these 5 received tandem HDCT/autoSCT as a salvage treatment. One patient died from sepsis during induction chemotherapy. The remaining 3 patients proceeded to tandem HDCT/autoSCT; however, 2 of these patients showed tumor relapse/progression after tandem HDCT/autoSCT. All 7 relapses/progressions occurred at primary sites even in patients with leptomeningeal seeding. Toxicities during tandem HDCT/autoSCT were manageable. A total of 5 patients were alive with a median follow-up of 20 (range 16-70) months from diagnosis. Four of 5 patients who received RI after relapse/progression are alive. The probability of overall survival at 3 yr from diagnosis was 53.3% +/- 17.3%. Our tandem HDCT/autoSCT is feasible; however, early administration of RT prior to tandem HDCT/autoSCT should be considered to improve the outcome after tandem HDCT/autoSCT.
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Collections - Medicine > Department of Medicine > 1. Journal Articles
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