A Facile One-Pot Synthesis of 1-Substituted Tetrazole-5-thiones and 1-Substituted 5-Alkyl(aryl)sulfanyltetrazoles from Organic Isothiocyanates
- Authors
- Han, SY[Han, Sam Yong]; Lee, JW[Lee, Je Woo]; Kim, HJ[Kim, Hee-Jung]; Kim, YJ[Kim, Yong-Joo]; Lee, SW[Lee, Soon W.]; Gyoung, YS[Gyoung, Young Soo]
- Issue Date
- 20-Jan-2012
- Publisher
- KOREAN CHEMICAL SOC
- Citation
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.33, no.1, pp.55 - 59
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- Volume
- 33
- Number
- 1
- Start Page
- 55
- End Page
- 59
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/66624
- DOI
- 10.5012/bkcs.2012.33.1.55
- ISSN
- 0253-2964
- Abstract
- Treatments of organic isothiocyanates (R-NCS) with NaN3 in the presence of pyridine in water at room temperature gave corresponding various organic tetrazole-thiones, [S=CN4(R)] (R = alkyl or aryl). Isolated products are obtained as white or yellow solids in good yields (76-97%). The molecular structure by X-ray diffraction study for one of products shows the proposed formation. In addition, one-pot synthesis of 1-substituted 5-alkyl(or aryl)sulfanyltetrazoles has been demonstrated. Addition of alkyl or aryl halides into the mixture of organic isothiocyanates, NaN3, and pyridine in water at room temperature exclusively formed 1-substituted 5-alkyl(or aryl)sulfanyltetrazoles (S-derivatives) in high yields.
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