Mutation analysis of NF-kappa B signal pathway-related genes in ocular MALT lymphoma
- Authors
- Liu, F[Liu, Fang]; Karube, K[Karube, Kennosuke]; Kato, H[Kato, Harumi]; Arita, K[Arita, Kotaro]; Yoshida, N[Yoshida, Noriaki]; Yamamoto, K[Yamamoto, Kiyoko]; Tsuzuki, S[Tsuzuki, Shinobu]; Kim, W[Kim, Wonseog]; Ko, YH[Ko, Young-Hyeh]; Seto, M[Seto, Masao]
- Issue Date
- 2012
- Publisher
- E-CENTURY PUBLISHING CORP
- Keywords
- Ocular adnexal lymphoma; TNFAIP3 (A20) deletion; N
- Citation
- INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, v.5, no.5, pp.436 - 441
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
- Volume
- 5
- Number
- 5
- Start Page
- 436
- End Page
- 441
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/67515
- ISSN
- 1936-2625
- Abstract
- Constitutive nuclear factor-kappa B (NF-kappa B) activation has been reported in ocular adnexal lymphoma (OAL). TNFAIP3/A20 is a "global" inhibitor of NF-kappa B pathway. We have shown that OAL has preferential loss of the 6q23.3 region where TNFAIP3/A20 exist, which is suggested to involve in lymphomagenesis of OAL. The mechanisms causing NF-kappa B activity in OAL remain elusive. Recently, NF-kappa B canonical pathway genes including CARD11, CD79B and MYD88 were shown to be frequently mutated in diffuse large B-cell lymphomas. In this study, we analyzed the mutation status of these genes by direct sequencing in 24 OAL cases including 9 cases with loss of 6q23.3 previously identified by array comparative genomic hybridization. We showed that genetic alterations of these genes were not found in OAL, a finding differing from that of most B-cell lymphomas. Genetic or epigenetic alterations in other genes are likely to be relevant in pathogenesis of OAL case without A20 loss.
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- Appears in
Collections - Medicine > Department of Medicine > 1. Journal Articles
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