The Role of Src Kinase inMacrophage-Mediated Inflammatory Responsesopen access
- Authors
- Byeon, SE[Byeon, Se Eun]; Yi, YS[Yi, Young-Su]; Oh, J[Oh, Jueun]; Yoo, BC[Yoo, Byong Chul]; Hong, S[Hong, Sungyoul]; Cho, JY[Cho, Jae Youl]
- Issue Date
- 2012
- Publisher
- HINDAWI PUBLISHING CORPORATION
- Citation
- MEDIATORS OF INFLAMMATION
- Indexed
- SCIE
SCOPUS
- Journal Title
- MEDIATORS OF INFLAMMATION
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/67680
- DOI
- 10.1155/2012/512926
- ISSN
- 0962-9351
- Abstract
- Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation. Many studies have shown that Src plays multiple roles in macrophage-mediated innate immunity, such as phagocytosis, the production of inflammatory cytokines/mediators, and the induction of cellular migration, which strongly implies that Src plays a pivotal role in the functional activation of macrophages. Macrophages are involved in a variety of immune responses and in inflammatory diseases including rheumatoid arthritis, atherosclerosis, diabetes, obesity, cancer, and osteoporosis. Previous studies have suggested roles for Src in macrophage-mediated inflammatory responses; however, recently, new functions for Src have been reported, implying that Src functions in macrophage-mediated inflammatory responses that have not been described. In this paper, we discuss recent studies regarding a number of these newly defined functions of Src in macrophage-mediated inflammatory responses. Moreover, we discuss the feasibility of Src as a target for the development of new pharmaceutical drugs to treat macrophage-mediated inflammatory diseases. We provide insights into recent reports regarding new functions for Src that are related to macrophage-related inflammatory responses and the development of novel Src inhibitors with strong immunosuppressive and anti-inflammatory properties, which could be applied to various macrophage-mediated inflammatory diseases.
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- Appears in
Collections - Biotechnology and Bioengineering > Integrative Biotechnology > 1. Journal Articles
- Biotechnology and Bioengineering > Department of Genetic Engineering > 1. Journal Articles
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