Effect of silk fibroin peptide derived from silkworm Bombyx mori on the anti-inflammatory effect of Tat-SOD in a mice edema modelopen access
- Authors
- Kim, DW[Kim, Dae Won]; Hwang, HS[Hwang, Hyun Sook]; Kim, DS[Kim, Duk-Soo]; Sheen, SH[Sheen, Seung Hoon]; Heo, DH[Heo, Dong Hwa]; Hwang, G[Hwang, Gyojun]; Kang, SH[Kang, Suk Hyung]; Kweon, H[Kweon, HaeYong]; Jo, YY[Jo, You-Young]; Kang, SW[Kang, Seok Woo]; Lee, KG[Lee, Kwang-Gill]; Park, KW[Park, Kye Won]; Han, KH[Han, Kyu Hyung]; Park, J[Park, Jinseu]; Eum, WS[Eum, Won Sik]; Cho, YJ[Cho, Yong-Jun]; Choi, HC[Choi, Hyun Chul]; Choi, SY[Choi, Soo Young]
- Issue Date
- 31-Dec-2011
- Keywords
- Inflammation; Protein therapy; Silk fibroin; Tat-superoxide dismutase; Tpa
- Citation
- BMB REPORTS, v.44, no.12, pp.787 - 792
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 44
- Number
- 12
- Start Page
- 787
- End Page
- 792
- URI
- https://scholarworks.bwise.kr/skku/handle/2021.sw.skku/68085
- DOI
- 10.5483/BMBRep.2011.44.12.787
- ISSN
- 1976-6696
- Abstract
- We investigated whether silk fibroin peptide derived from the silkworm, Bombyx mori, could inhibit inflammation and enhance the anti-inflammatory activity of Tat-superoxide dismutase (Tat-SOD), which was previously reported to effectively penetrate various cells and tissues and exert anti-oxidative activity in a mouse model of inflammation. Inflammation was induced by topical treatment of mouse ears with 12-O-tetradecanoylphorbol-13-acetate (TPA). Histological, Western blot, and reverse transcription-polymerase chain reaction data demonstrated that silk fibroin peptide or Tat-SOD alone could suppress elevated levels of cyclooxygenase-2, interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha induced by TPA. Moreover, silk fibroin peptide significantly enhanced the anti-inflammatory activity of Tat-SOD, although it had no influence on in vitro and in vivo transduction of Tat-SOD. Silk fibroin peptide exhibited anti-inflammatory activity in a mice model of inflammation. Therefore, silk fibroin peptide alone or in combination with Tat-SOD might be used as a therapeutic agent for various inflammatory diseases. [BMB reports 2011; 44(12): 787-792]
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Collections - Biotechnology and Bioengineering > Department of Food Science and Biotechnology > 1. Journal Articles
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